Quiescent Adult Neural Stem Cells:Developmental Origin and Regulatory Mechanisms  

作　　者：Han Meng Yu Huan Kun Zhang Xuyang Yi Xinyu Meng Enming Kang Shengxi Wu Wenbing Deng Yazhou Wang 

机构地区：[1]Department of Neurobiology and Institute of Neurosciences,School of Basic Medicine,Fourth Military Medical University,Xi’an,710032,China [2]Department of Neurosurgery,General Hospital of Northern Theater Command,Shenyang,110016,China [3]School of Life Science and Research Center for Natural Peptide Drugs,Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources,Yanan University,Yan’an,716000,China [4]School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Shenzhen,510631,China

出　　处：《Neuroscience Bulletin》2024年第9期1353-1363,共11页神经科学通报（英文版）

基　　金：National Natural Science Foundation of China(31970907 and 82171346).

摘　　要：The existence of neural stem cells(NSCs)in the adult mammalian nervous system,although small in number and restricted to the sub-ventricular zone of the lateral ventricles,the dentate gyrus of the hippocampus,and the olfactory epithelium,is a gift of evolution for the adaptive brain function which requires persistent plastic changes of these regions.It is known that most adult NSCs are latent,showing long cell cycles.In the past decade,the concept of quiescent NSCs(qNSCs)has been widely accepted by researchers in the field,and great progress has been made in the biology of qNSCs.Although the spontaneous neuronal regeneration derived from adult NSCs is not significant,understanding how the behaviors of qNSCs are regulated sheds light on stimulating endogenous NSC-based neuronal regeneration.In this review,we mainly focus on the recent progress of the developmental origin and regulatory mechanisms that maintain qNSCs under normal conditions,and that mobilize qNSCs under pathological conditions,hoping to give some insights for future study.

关 键 词：Quiescent Neural stem cell Neuronal regeneration INJURY 

分 类 号：R745[医药卫生—神经病学与精神病学]