ZIP4 inhibits Ephrin-B1 ubiquitination,activating Wnt5A/JNK/ZEB1 to promote liver cancer metastasis  

作　　者：Haijun Guo Renyi Su Xinfeng Lu Hui Zhang Xuyong Wei Xiao Xu 

机构地区：[1]Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310006,China [2]Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China [3]The Fourth School of Clinical Medicine,Zhejiang Chinese Medicine University,Hangzhou,Zhejiang 310053,China [4]School of Clinical Medicine,Hangzhou Medical College,Hangzhou,Zhejiang 310014,China

出　　处：《Genes & Diseases》2024年第6期1-4,共4页基因与疾病（英文）

基　　金：supported by Zhejiang Provincial Natural Science Foundation of China (No.LQ20H160029);The Construction Fund of Key Medical Disciplines of Hangzhou,Zhejiang,China (No.0020200093);The Major Research Plan of the National Natural Science Foundation of China (No.92159202);The Key Program,National Natural Science Foundation of China (No.81930016);The Key Research&Development Plan of Zhejiang Province,China (No.2019C03050).

摘　　要：Hepatocellular carcinoma(HCC),a highly malignant tumor,faces a major challenge with its high post-hepatectomy recurrence impacting patient survival.Mechanisms and preventive strategies remain to be resolved.Zrt-/lrt-like protein 4(ZIP4,also called SLC39A4/solute carrier family 39 member 4)belongs to the zinc transporter ZiP superfamily of which the members play an important role in maintaining zinc steady state,and its high expression in various tumors is associated with the prognosis of cancer patients.

关 键 词：ZEB1 METASTASIS cancer 

分 类 号：R735.7[医药卫生—肿瘤]