Adeno-associated virus-mediated intraprostatic suppression of MIR375 inhibits tumor progression in the TRAMP mouse nmodel of prostate cancer  

作　　者：Xianyanling Yi Jin Li Zeyu Han Tianyi Zhang Dazhou Liao Jia You Jianzhong Ai 

机构地区：[1]Department of Urology/lnstitute of Urology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Genes & Diseases》2024年第6期40-42,共3页基因与疾病（英文）

基　　金：supported by the National Key R&D Plan (2023YFC3403200);grants from the National Natural ScienceFoundation of China (No.82070784and 81702536);a grant from the Science&Technology Department of Sichuan Province,China (No.2022JDRC0040).

摘　　要：The treatment of prostate cancer(PCa)needs to be improved.1 Micro-RNAs(miRNAs)are a subtype of non-coding,single-stranded RNAs that influence cellular survival and death by modulating mRNAs.Among these miRNAs,MIR375 has a critical role in the regulation of tumorigenesis?and holds promise as a novel therapeutic target for future PCa treatment.Recombinant adeno-associated virus(rAAV)exhibits non-pathogenicity,low-grade inflammation,and robust and long-lasting expressions of target genes.We have previously described the rAAv9 as a valid vector to transfer target miRNAs and genes,3 so rAAv9 could be used as a vector to deliver MIR375 into the mouse prostate and PCa cells.

关 键 词：cancer INFLAMMATION holds 

分 类 号：R737.25[医药卫生—肿瘤]