NRF2 in age-related musculoskeletal diseases:Role and treatment prospects  

作　　者：Xiangyu Zhang Hengzhen Li Lin Chen Yuxiang Wu Yusheng Li 

机构地区：[1]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [3]Department of Health and Physical Education,Jianghan University,Wuhan,Hubei 430056,China

出　　处：《Genes & Diseases》2024年第6期295-314,共20页基因与疾病（英文）

基　　金：supported by the National Key R&D Program of China (No.2019YFA0111900);the National Natural Science Foundation of China (No.82072506,92268115,82071970,81971775);the Science Fund for Distinguished Young Scholars of Hubei Province (No.2023AFA109);the Science and Technology Innovation Program of Hunan Province (No.2021RC3025);the Independent Exploration and Innovation Project for Postgraduate Students of Central South University (China) (No.2022ZZTS0268);Hunan Provincial Innovation Foundation for Postgraduate (No.CX20220350);the Science and Technology Project of Jianghan University (No.2022SXZX25);the Science and Technology Innovation Project of Jianghan University (China) (No.2021kjzx008).

摘　　要：The NRF2 pathway is a metabolic-and redox-sensitive signaling axis in which the transcription factor controls the expression of a multitude of genes that enable cells to survive environmental stressors,such as oxidative stress,mainly by inducing the expression of cytopro-tective genes.Basal NRF2 levels are maintained under normal physiological conditions,but when exposed to oxidative stress,cells activate the NRF2 pathway,which is crucial for sup-porting cell survival.Recently,the NRF2 pathway has been found to have novel functions in metabolic regulation and interplay with other signaling pathways,offering novel insights into the treatment of various diseases.Numerous studies have shown that targeting its pathway can effectively investigate the development and progression of age-related musculoskeletal dis-eases,such as sarcopenia,osteoporosis,osteoarthritis,and intervertebral disc degeneration.Appropriate regulation of the NRF2 pathway flux holds promise as a means to improve muscu-loskeletal function,thereby providing a new avenue for drug treatment of age-related muscu-loskeletal diseases in clinical settings.The review summarized an overview of the relationship between NRF2 and cellular processes such as oxidative stress,apoptosis,inflammation,mito-chondrial dysfunction,ferroptosis,and autophagy,and explores the potential of targeted NRF2 regulation in the treatment of age-related musculoskeletal diseases.

关 键 词：Intervertebral disc degeneration NRF2 OSTEOARTHRITIS OSTEOPOROSIS SARCOPENIA 

分 类 号：R68[医药卫生—骨科学]