PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging  

作　　者：Lingqi Xie Yalun Cheng Biao Hu Xin Chen Yuze An Zhuying Xia Guangping Cai Changjun Li Hui Peng 

机构地区：[1]Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha,Hunan 410008,China [3]Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Changsha,Hunan 410008,China

出　　处：《Bone Research》2024年第3期595-610,共16页骨研究（英文版）

基　　金：supported by the National Key R&D Program of China (2021YFC2501702);the National Natural Science Foundation of China,China (grant nos.82270911,82201746,82000848,82300998);the National Key Research and Development Plan (2022YFC3601900,2022YFC3601901,2022YFC3601902,2022YFC3601903,2022YFC3601904,and 2022YFC3601905);the Key Research and Development Program of Hunan Province,China (2022WK2010)。

摘　　要：Bone marrow adipocytes(BMAds)affect bone homeostasis,but the mechanism remains unclear.Here,we showed that exercise inhibited PCNA clamp-associated factor(PCLAF)secretion from the bone marrow macrophages to inhibit BMAds senescence and thus alleviated skeletal aging.

关 键 词：SKELETAL inhibited HOMEOSTASIS 

分 类 号：R68[医药卫生—骨科学]