氟在口腔微生态作用中的研究进展  

Research progress in the effects of fluoride on oral microecology

作　　者：杨洁如 吕文飞 胡欢 任群利 王苗 李小兰 刘建国 王倩 YANG Jieru;LV Wenfei;HU Huan;REN Qunli;WANG Miao;LI Xiaolan;LIU Jianguo;WANG Qian(Guizhou Provincial Key Laboratory of Oral Disease Research,School of Stomatology,Zunyi Medical University,Zunyi 563000,Guizhou,China;Guizhou Provincial Key Laboratory of Microbial Resources and Drug Development,Zunyi Medical University,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学口腔医学院,贵州省普通高校口腔疾病研究特色重点实验室,贵州遵义563000 [2]遵义医科大学贵州省普通高校微生物资源与药物开发特色重点实验室,贵州遵义563000

出　　处：《微生物学通报》2024年第10期3836-3846,共11页Microbiology China

基　　金：贵州省教育厅2022乡村振兴集成示范村建设项目(黔教技[2022]037号);遵义医科大学优秀青年人才项目(17zy-002)。

摘　　要：氟一直是被广泛使用的有效抗龋成分,氟离子能通过抑制微生物代谢关键酶的活性或改变细胞膜通透性来抑制细菌生长,显著抑制变异链球菌(Streptococcus mutans)等主要致龋菌,还能改变龋病患者的口腔微生物组结构。但长期过量使用氟会导致口腔耐氟菌株出现,降低氟化物防龋效果。随着高通量测序技术的进步,有助于学者们深入研究口腔微生物氟抗性的分子机制及氟对口腔微生态的影响。近年来氟与新型生物医用材料的联用为耐氟菌株提供了新的防治思路。本文围绕口腔微生物氟抗性的产生及其分子机制、氟对人口腔微生物组的影响,以及氟与新型材料联合运用等方面,对氟在口腔微生态中的影响及作用进行了全面综述,旨在为氟在口腔健康领域的进一步研究和应用提供理论基础。Fluoride has been used as an effective anti-caries agent for decades.Fluorinion can inhibit the activities of key enzymes in microbial metabolism or change the permeability of cell membrane,thus inhibiting the growth of major cariogenic bacteria such as Streptococcus mutans.Moreover,it can change the oral microbiome structure of caries patients.However,the long-term excessive use of fluoride may lead to the emergence of fluoride-resistant strains and reduce the anti-caries effect of fluoride.The development of sequencing technology enables researchers to gain deep understanding of fluoride resistance mechanism in oral microorganisms and the influence of fluoride on oral microecology.In recent years,the combination of fluorine and new biomedical materials provides a new strategy for controlling fluorine-resistant strains.This paper reviews the latest studies about the effects of fluoride on oral microecology,including the generation and mechanism of fluoride resistance in oral microorganisms,the effects of fluoride on human oral microbiome,and the combined use of fluorine and new biomedical materials,aiming to provide a theoretical basis for the further research and application of fluoride in oral health.

关 键 词：氟 抗菌机制 口腔微生态 氟抗性 生物医用材料 

分 类 号：R780.2[医药卫生—口腔医学]