Periodontitis and chronic kidney disease:A bidirectional relationship based on inflammation and oxidative stress  

作　　者：Melissa Martínez Nieto Martha Leticia De Leon Rodríguez Rocio del Carmen Anaya Macias Sarah Monserrat LomelíMartínez 

机构地区：[1]Independent Researcher,Tijuana 22116,Baja California,Mexico [2]Department of Medical and Life Sciences,Centro Universitario de la Ciénega,Centro Universitario de la Ciénega,Universidad de Guadalajara,Ocotlan 47810,Jalisco,Mexico [3]Department of Medical and Life Sciences,Centro Universitario de la Ciénega,Universidad de Guadalajara,Ocotlán 47810,Mexico [4]Master of Public Health,Department of Well-being and Sustainable Development,Centro Universitario del Norte,Universidad de Guadalajara,Colotlan 46200,Jalisco,Mexico

出　　处：《World Journal of Clinical Cases》2024年第35期6775-6781,共7页世界临床病例杂志（英文）

摘　　要：Chronic kidney disease(CKD)and chronic periodontitis(CP)are prevalent conditions which significantly impact public health worldwide.Both diseases share inflammatory and oxidative stress mechanisms,an indication of a likely bidirectional relationship.This editorial explored the association between CKD and CP by highlighting common inflammatory mechanisms and recent research findings that address this interrelationship.Through reviews of recent studies,we discussed how periodontal bacteria may activate systemic immune responses that affect both periodontal and renal tissues.Additionally,meta-analysis data indicated an increased risk of CKD development in patients with CP,and vice versa.The results suggest the need for more rigorous research in the future in order to address the confounding factors and evaluate specific periodontal health interventions and their direct effects on kidney function.We emphasized the importance of comprehensive and multidisciplinary care for the improvement of the overall health of patients affected by CP and CKD.

关 键 词：PERIODONTITIS Chronic kidney disease Periodontal disease Oxidative stress INFLAMMATION 

分 类 号：R781.42[医药卫生—口腔医学] R692[医药卫生—临床医学]