Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis  

作　　者：Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu 

机构地区：[1]Department of The Breast Center,Cancer Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China [2]Department of General Surgery,First Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China

出　　处：《World Journal of Clinical Oncology》2025年第1期10-24,共15页世界临床肿瘤学杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82273457;the Natural Science Foundation of Guangdong Province,No.2023A1515012762 and No.2021A1515010846;Special Grant for Key Area Programs of Guangdong Department of Education,No.2021ZDZX2040;Science and Technology Special Project of Guangdong Province,No.210715216902829.

摘　　要：The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including humans.Comprising six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX family.Dysregulation or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular functions.Efforts to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor development.While the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic advances.Therefore,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular carcinomas.In conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关 键 词：Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis THERAPEUTICS 

分 类 号：R735[医药卫生—肿瘤]