Preventive effect of probiotics on infections following colorectal cancer surgery:An umbrella meta-analysis  

作　　者：Yue Han Yong Wang Min Guan 

机构地区：[1]Department of Gastrointestinal Surgery,Shandong Provincial Third Hospital,Shandong University,Jinan 250031,Shandong Province,China [2]Department of Hepatobiliary Surgery,Shandong Provincial Third Hospital,Shandong University,Jinan 250031,Shandong Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第11期3546-3558,共13页世界胃肠外科杂志（英文）

摘　　要：BACKGROUND Postoperative infections remain a significant source of morbidity among patients undergoing colorectal cancer(CRC)surgery.While probiotics have been pro-posed as a potential strategy to mitigate the risk of these infections,contemporary meta-analyses have produced conflicting findings.AIM To synthesize the available evidence regarding the prophylactic efficacy of probiotics in preventing infections following CRC surgery.METHODS A comprehensive search of PubMed and Scopus was conducted to identify relevant meta-analyses published up to February 2024.To assess the efficacy of probiotics on outcomes,relative risks(RR)and their corresponding 95%CI were pooled using a random effects model.RESULTS This comprehensive umbrella meta-analysis integrated eleven meta-analyses encompassing 11518 participants who fulfilled the inclusion criteria.Probiotics administration resulted in a statistically significant reduction in the incidence of total infections(RR:0.40,95%CI:0.31-0.51;moderate certainty),surgical site infections(RR:0.56,95%CI:0.49-0.63;high certainty),pneumonia(RR:0.38,95%CI:0.30-0.48;high certainty),urinary tract infections(RR:0.44,95%CI:0.31-0.61;moderate certainty),bacteremia(RR:0.41,95%CI:0.30-0.56;high certainty),and sepsis(RR:0.35,95%CI:0.25-0.44;high certainty).However,probiotics did not significantly affect intra-abdominal,central line,or peritoneal infections.CONCLUSION Probiotics have demonstrated potential in mitigating postoperative infectious complications among patients undergoing CRC surgery.

关 键 词：PROBIOTICS Colorectal cancer Surgery Postoperative infections Pneumonia Urinary tract infections BACTEREMIA SEPSIS META-ANALYSIS 

分 类 号：R735.34[医药卫生—肿瘤]