Insights of gut-liver axis in hepatic diseases:Mechanisms,clinical implications,and therapeutic potentials  

作　　者：Naveen Jeyaraman Madhan Jeyaraman Tejaswin Mariappan Sathish Muthu Swaminathan Ramasubramanian Shilpa Sharma Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana 

机构地区：[1]Department of Orthopaedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [2]Department of Research Methods,Orthopaedic Research Group,Coimbatore 641045,Tamil Nadu,India [3]Department of Orthopaedics,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,São Paulo,Brazil [4]Department of Community Medicine,Government Stanley Medical College and Hospital,Chennai 600001,Tamil Nadu,India [5]Department of Orthopaedics,Government Medical College,Karur 639004,Tamil Nadu,India [6]Department of Biotechnology,Faculty of Engineering,Karpagam Academy of Higher Education,Coimbatore 641021,Tamil Nadu,India [7]Department of Orthopaedics,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India [8]Department of Paediatric Surgery,All India Institute of Medical Sciences,New Delhi 110029,India

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第6期1-17,共17页世界胃肠药理与治疗学杂志（英文）

摘　　要：With the rising prevalence of chronic liver diseases worldwide,there exists a need to diversify our artillery to incorporate a plethora of diagnostic and therapeutic methods to combat this disease.Currently,the most common causes of liver disease are non-alcoholic fatty liver disease,hepatitis,and alcoholic liver disease.Some of these chronic diseases have the potential to transform into hepatocellular carcinoma with advancing fibrosis.In this review,we analyse the relationship between the gut and liver and their significance in liver disease.This two-way relationship has interesting effects on each other in liver diseases.The gut microbiota,through its metabolites,influences the metabolism in numerous ways.Careful manipulation of its composition can lead to the discovery of numerous therapeutic potentials that can be applied in the treatment of various liver diseases.Numerous cohort studies with a pan-omics approach are required to understand the association between the gut microbiome and hepatic disease progression through which we can identify effective ways to deal with this issue.

关 键 词：Gut-liver axis DYSBIOSIS Liver disease PROBIOTICS Fecal microbiota transplantation Precision medicine 

分 类 号：R575[医药卫生—消化系统]