Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation  

作　　者：Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz 

机构地区：[1]Department of Neurosurgery,University of Health Sciences Turkey,Gaziosmanpaşa Training and Research Hospital,Istanbul 34255,Türkiye [2]Department of Pediatric Allergy-Immunology,Institute of Health Sciences Marmara University,Istanbul 34865,Türkiye [3]Center for Stem Cell&Gene Therapy Research and Practice,University of Health Sciences Turkey,Istanbul 34255,Türkiye [4]Department of Child and Adolescent Psychiatry,University of Health Sciences,Gaziosmanpaşa Training and Research Hospital,Istanbul 34255,Türkiye [5]Department of Child and Adolescent Psychiatry,Kocaeli University Faculty of Medicine,Kocaeli 41001,Türkiye [6]Center for Regenerative Medicine and Stem Cell Research&Manufacturing,Liv Hospital,Istanbul 34340,Türkiye [7]Department of Histology and Embryology,Istinye University,Faculty of Medicine,Istanbul 34010,Türkiye [8]Center for Stem Cell and Tissue Engineering Research and Practice,Istinye University,Istanbul 34340,Türkiye

出　　处：《World Journal of Methodology》2025年第1期72-79,共8页世界方法学杂志（英文）

摘　　要：BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted origins.In recent studies,neuroinflammation and immune dysregulation have come to the forefront in its pathogenesis.There are studies suggesting that stem cell therapy may be effective in the treatment of ASD.AIM To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell transplantation.METHODS A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with neurorehabilitation.RESULTS The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor skills.No serious side effects were encountered during the 2-year follow-up.CONCLUSION The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关 键 词：Autism spectrum disorder NEUROREHABILITATION Stem cell transplantation Wharton jelly mesenchymal stem cells INFLAMMATION 

分 类 号：R749.4[医药卫生—神经病学与精神病学]