中链甘油三酯中甘油二酯的分离与结构鉴定  

Isolation and identification of diglycerides from medium-chain triglycerides

作　　者：王国财 唐顺之 袁诚 李继荣 牟肖男 许文东 WANG Guocai;TANG Shunzhi;YUAN Cheng;LI Jirong;MU Xiaonan;XU Wendong(Guangdong Provincial Key Laboratory of Medicinal Lipid,National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation,Guangzhou Hanfang Pharmaceutical Co.,Ltd,Guangzhou 510006,China)

机构地区：[1]广州白云山汉方现代药业有限公司,中药制药过程技术与新药创制国家工程研究中心,广东省药用脂质重点实验室,广州510006

出　　处：《中国油脂》2024年第11期81-84,105,共5页China Oils and Fats

基　　金：广东省科技计划项目“广东省药用脂质重点实验室”(2023B1212070030)。

摘　　要：旨在阐明中链甘油三酯产品中的主要副产物甘油二酯类杂质的化学成分,以中链甘油三酯为原料,通过硅胶柱层析和半制备高效液相色谱法分离其中的甘油二酯,并通过核磁谱、质谱、红外光谱、紫外光谱和气相色谱对甘油二酯的结构进行鉴定。结果表明:从中链甘油三酯中分离出6种甘油二酯(DG-1~DG-6),结构依次被鉴定为1,3-二辛酸甘油二酯、1,2-二辛酸甘油二酯、1,3-辛酸癸酸甘油二酯、1,2-辛酸癸酸甘油二酯、1,3-二癸酸甘油二酯、1,2-二癸酸甘油二酯。了解中链甘油三酯中甘油二酯的结构有助于中链甘油三酯的质量控制和临床应用。To clarify the chemical composition of diglycerides impurities,a major by-product in medium-chain triglycerides products,diglycerides were isolated from medium-chain triglycerides through silica gel column and semipreparative high performance liquid chromatography,and the structures of diglycerides were identified.The results showed that six diglycerides(DG-1-DG-6)were isolated from medium-chain triglycerides,and the structures of DG-1-DG-6 were identified as 1,3-dicaprylin glycerate,1,2-dicaprylin glycerate,1,3-caprylin,caprin glycerate,1,2-caprylin,caprin glycerate,1,3-dicaprin glycerate,1,2-dicaprin glycerate by nuclear magnetic spectrum,mass spectrum,IR spectrum,ultraviolet spectrum,and gas chromatography.Knowing the structure of diglycerides in medium-chain triglycerides is conducive to the quality control and clinical application of medium-chain triglycerides.

关 键 词：中链甘油三酯 甘油二酯 分离 鉴定 

分 类 号：TS228[轻工技术与工程—粮食、油脂及植物蛋白工程] TQ646[轻工技术与工程—食品科学与工程]