青稞汁及其乳酸发酵饮品对db/db小鼠糖脂代谢和肠道菌群的影响  

The effects of highland barley juice and its lactic acid fermented beverage on glucose and lipid metabolism and intestinal flora in db/db mice

作　　者：张静 于佳俊 文华英 王妍凌 张凤杰 金玮鋆 张玉红 薛洁 ZHANG Jing;YU Jiajun;WEN Huaying;WANG Yanling;ZHANG Fengjie;JIN Weiyun;ZHANG Yuhong;XUE Jie(China National Research Institute of Food and Fermentation Industries Co.Ltd.,Beijing 100015,China;National International Joint Research Center for Liquor Quality and Safety,Beijing 100015,China;Institute of Food Science and Technology,Tibet Academy of Agricultural and Animal Husbandry Sciences,Lhasa 850000,China)

机构地区：[1]中国食品发酵工业研究院有限公司,北京100015 [2]国家酒类品质与安全国际联合研究中心,北京100015 [3]西藏自治区农牧科学院农产品开发与食品科学研究所,西藏拉萨850000

出　　处：《食品与发酵工业》2024年第21期68-75,共8页Food and Fermentation Industries

基　　金：西藏特色食品资源高质化利用关键技术研发与应用(西藏自治区科技攻关计划)(XZ202201ZD0001N)。

摘　　要：在目前的Ⅱ型糖尿病(type 2 diabetes,T2DM)研究领域中,由于青稞具有低糖指数和富含膳食纤维的特性,吸引了广泛的科学关注,并有望成为改善血糖控制的潜在策略。该研究旨在探讨青稞汁及其乳酸发酵饮品对db/db小鼠糖脂代谢的调节效果和肠道菌群的影响。对25只db/db小鼠进行为期4周的青稞饮品干预,监测体重、血糖相关生化指标和微生物多样性。结果表明,青稞汁及其乳酸发酵饮品通过不同机制调节小鼠的血糖和血脂水平。乳酸发酵饮品在血糖控制上表现出显著效果,同时改善了血脂代谢,降低了甘油三酯和总胆固醇水平,并促使肠道中有益菌群的富集。综上所述,研究深入剖析了青稞汁及其乳酸发酵饮品与糖脂代谢的潜在联系,为T2DM的治疗和管理提供了新的思路和方向。Research in the realm of type 2 diabetes mellitus(T2DM)has recently highlighted highland barley as a promising dietary intervention due to its low glycemic index and high fiber content.This study investigated the effects of highland barley juice and its lactic acid-fermented derivative on glucose and lipid metabolism,as well as their influence on gut microbiota in db/db mice.Over a four-week period,25 db/db mice received these barley-based interventions,with subsequent assessments of body weight,glycemic biomarkers,and microbial diversity.The findings revealed distinct mechanisms by which highland barley juice and its lactic acid-fermented counterpart modulate blood glucose and lipid profiles.The fermented beverage,in particular,demonstrated significant glycemic control,alongside improvements in lipid metabolism indicated by reduced triglyceride and total cholesterol levels.Additionally,it was associated with an increase in beneficial gut microbial populations.In essence,this study elucidated the differential impact of highland barley juice and its fermented version on metabolic parameters in T2DM,suggesting a beneficial role in disease management.The results advocated for further exploration into the use of highland barley-based products as a dietary strategy for improving T2DM outcomes.This work not only contributes to the understanding of functional foods in glycemic regulation but also underscores the potential synergistic relationship between diet,metabolic health,and gut microbiota composition.

关 键 词：青稞 T2DM 血糖调节 肠道菌群 

分 类 号：TS201.4[轻工技术与工程—食品科学]