Uncovering chromatin accessibility and cancer diagnostic potential via cell-free DNA utilization  

通过利用细胞游离DNA揭示染色质开放性及癌症诊断潜力

作　　者：Jie Li Jiahui Chen Xin Sun Heli Yang Keyong Sun Chang Liu Yongwang Wang Mengyue Xu Xin Ji Ji Zhang Xiaojiang Wu Anqiang Wang Biao Fan Xiaolu Zhang Yue Wu Peilin Cui Junya Peng Yupei Zhao Wenming Wu Honghao Yu Zhaode Bu Jiafu Ji Xun Lan 李杰;陈佳辉;孙欣;杨合利;孙克用;刘畅;王永旺;徐梦悦;季鑫;张霖;吴晓江;王安强;范彪;张晓璐;吴越;崔培林;彭俊雅;赵玉沛;吴文铭;于鸿浩;步召德;季加孚;蓝勋

机构地区：[1]Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing 100084,China [2]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Center of Gastrointestinal Cancer,Peking University Cancer Hospital&Institute,Beijing 100142,China [3]Guangxi Key Laboratory of Drug Discovery and Optimization,Guilin Medical University,Guilin 541001,China [4]Department of General Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Beijing 100730,China [5]Department of Internal Medicine,International Medical Services(IMS),Beijing Tiantan Hospital of Capital Medical University,Beijing 100070,China [6]Institute of Clinical Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China [7]Academy of Biomedical Engineering,Kunming Medical University,Kunming 650500,China [8]MOE Key Laboratory of Bioinformatics,Tsinghua University,Beijing 100084,China [9]Peking-Tsinghua-NIBS Joint Graduate Program,Tsinghua University,Beijing 100084,China [10]Tsinghua-Peking Joint Center for Life Sciences,Tsinghua University,Beijing 100084,China [11]Department of Anesthesiology,Affiliated Hospital of Guilin Medical University,Guilin 541000,China [12]Key Laboratory of Medical Biotechnology and Translational Medicine,Guilin Medical University,Guilin 541001,China [13]State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China [14]Department of Gastric Surgery,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou 310022,China [15]The Islands Healthcare Complex-Macao Medical Center of Peking Union Medical College Hospital,Macao 999078,China

出　　处：《Science Bulletin》2024年第19期2987-2992,共6页科学通报（英文版）

基　　金：supported by Beijing Natural Science Foundation(Z190022);the National Natural Science Foundation of China(81972680,82141102,52271254,82072748,82141102,and 82072748);a start-up fund from Tsinghua University-Peking University Joined Center for Life Science,Guangxi One Thousand Young and Middle-Aged College and University Backone Teachers Cultivation Program,the CAMS Innovation Fund for Medical Sciences(2021-12M-1-002 and 2023-12M-2-002);the National High Level Hospital Clinical Research Funding(2022-PUMCH-D-001,2022-PUMCH-A-082);the National Key Research and Development Program of China(2020YFA0803702);the Science Foundation of Peking University Cancer Hospital(PY202330).

摘　　要：Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at promoters.However,the direct relationship between cfDNA patterns and tumor-specific chromatin accessibility has not yet been experimentally established,limiting its current application to cancer diagnosis alone.

关 键 词：diagnosis CANCER ALONE 

分 类 号：R730.4[医药卫生—肿瘤]