RAS基因突变在甲状腺癌中的研究进展  

Progress of RAS gene mutation in thyroid cancer

作　　者：周旭阳 王鑫宇 宋文晓 史亚飞[2] Zhou Xuyang;Wang Xinyu;Song Wenxiao;Shi Yafei(Clinical Medical College of Jining Medical University,Jining 272000,China;Department of Thyroid Surgery,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院临床医学院,济宁272000 [2]济宁医学院附属医院甲状腺外科,济宁272000

出　　处：《肿瘤研究与临床》2024年第9期713-716,共4页Cancer Research and Clinic

摘　　要：近20年来甲状腺癌的发病率呈现明显上升趋势,在女性患者中尤为突出。大鼠肉瘤病毒基因(RAS)突变作为甲状腺癌第二常见的分子标志物,主要通过RAS-RAF-MEK-ERK和PI3K-AKT信号通路来影响甲状腺癌的发生及发展,但RAS突变对甲状腺癌的侵袭性特征以及预后和生存率的影响仍有争议。现就RAS基因突变在甲状腺癌中的研究进展进行综述。In recent 20 years,the incidence of thyroid cancer has shown an obvious upward trend,especially in female patients.As the second most common molecular marker of thyroid cancer,RAS mutation affects the occurrence and development of thyroid cancer mainly through RAS-RAF-MEK-ERK and PI3K-Akt signaling pathways.However,the effect of RAS mutation on the invasive characteristics,prognosis and survival rate of thyroid cancer is still controversial.This article reviews the research progress of RAS gene mutation in thyroid cancer.

关 键 词：甲状腺肿瘤 基因 ras 突变 分子靶向治疗 

分 类 号：R736.1[医药卫生—肿瘤]