褐藻多糖改善肥胖及其并发症的研究进展  

Research Progress of Fucoidan in Improving Obesity and Complications

作　　者：伍洋[1,2,3] 武涌 陈红兵[1,3,4] 金雪玲 黄道武[6] 余秀梅 郑双艳[1,2,3] WU Yang;WU Yong;CHEN Hongbing;JIN Xueling;HUANG Daowu;YU Xiumei;ZHENG Shuangyan(Sino-German Joint Research Institute,Nanchang University,Nanchang 330047,China;College of Food Science and Technology,Nanchang University,Nanchang 330047,China;Jiangxi Province Key Laboratory of Food Allergy,Nanchang University,Nanchang 330047,China;State Key Laboratory of Food Science and Resources,Nanchang University,Nanchang 330047,China;The First Affiliated Hospital,Nanchang University,Nanchang 330047,China;Zhengying Foods Co.,Ltd.,Yichun 336000,China)

机构地区：[1]南昌大学中德联合研究院,江西南昌330047 [2]南昌大学食品学院,江西南昌330047 [3]江西省食物过敏重点实验室,江西南昌330047 [4]南昌大学食品科学与资源挖掘全国重点实验室,江西南昌330047 [5]南昌大学第一附属医院,江西南昌330047 [6]正盈食品有限公司,江西宜春336000

出　　处：《食品工业科技》2024年第22期383-389,共7页Science and Technology of Food Industry

基　　金：国家自然科学基金(32260631);江西省自然科学基金项目(20212BAB205034)。

摘　　要：肥胖问题日益严重,伴随而来的肥胖并发症如血脂异常、非酒精性脂肪肝、氧化损伤、全身性炎症严重威胁着人类健康。褐藻多糖是从棕色海藻以及部分海洋无脊椎动物中提取的生物活性多糖,具有改善肥胖及其并发症等疾病的功效,逐渐成为当前的研究热点。本文举例介绍了当前国内外褐藻多糖在食品、药品和医学方面的部分应用,并讨论了当前的不足,为进一步研究褐藻多糖功效和开发新产品提供参考。Obesity,a serious and growing issue,is associated with metabolic complications like dyslipidemia,non-alcoholic fatty liver disease,oxidative stress,and systemic inflammation.These complications pose a severe threat to human health.Fucoidan,a bioactive polysaccharide extracted from brown algae and certain marine invertebrates,holds the potential to ameliorate obesity and its associated diseases,thus becoming a current research hotspot.As a dietary supplement,fucoidan enhances obesity by modulating fat synthesis and breakdown,adipocyte differentiation and basal energy metabolism,as well as the abundance and beneficial bacteria ratio of intestinal microbiota.Additionally,fucoidan alleviates obesity-related diseases by reducing liver fat accumulation and lipotoxicity,lowering blood lipid levels and insulin resistance,promoting macrophage M1 to M2 polarization and the release of anti-inflammatory cytokines,and eliminating reactive oxygen species and lipid peroxidation products.This article presents some of the current applications of fucoidan in the food,medicine,and medical fields,and discusses the existing limitations,providing references for further research on fucoidan efficacy and new product development.

关 键 词：褐藻多糖 海藻 肥胖 膳食补充剂 并发症 

分 类 号：TS201.2[轻工技术与工程—食品科学]