Antimicrobial susceptibility of vancomycin-resistant staphylococci of clinical origin in Bareilly, North India  

作　　者：Bhoj Raj Singh Himani Agri Akanksha Yadav Varsha Jayakumar Abhijit Motiram Pawde 

机构地区：[1]Division of Epidemiology,ICAR-Indian Veterinary Research Institute,Izatnagar 243122,India [2]Centre for Wildlife,ICAR-Indian Veterinary Research Institute,Izatnagar 243122,India.

出　　处：《Infectious Diseases Research》2024年第4期1-12,共12页传染病研究（英文）

基　　金：supported by grants received from CAAST-ACLH(NAHEP/CAAST/2018-19);ICAR-World Bank-funded National Agricultural Higher Education Project(NAHEP).

摘　　要：Background:Vancomycin resistance(VR)in staphylococci is emerging fast and posing serious health problems as vancomycin is considered the drug of choice for the treatment of methicillin-resistant staphylococcal infections.Much research has been done on vancomycin-resistant Staphylococcus aureus(VRSA)strains infecting humans and animals but little is understood about other vancomycin-resistant staphylococci(VRS).This study was conducted to determine diversity among staphylococcal species causing infections and to know effective antimicrobials for therapeutic intervention for treatment of infections with vancomycin resistant staphylococci.Methods:Antimicrobial susceptibility data of 620 strains of staphylococci isolated from January 2016 to December 2023 from referred clinical samples were retrieved with their host of origin and association with different types of infections in animals,birds and humans from Clinical Epidemiology of the Institute.All isolates were tested for VR through their growing ability on vancomycin-supplemented(6µg mL-1)brain heart infusion agar.Data was analysed in Microsoft Excel.Results:Staphylococci strains(620)belonged to 26 species and 287 vancomycin-resistant.Of the 287 VRS strains detected only 46(16.03%)were VRSA.Irrespective of their origin and association with different ailments VRS strains were more resistant to herbal and conventional antimicrobial than VSS strains.The most effective antibiotics inhibiting≥80%of the staphylococci were tigecycline,imipenem,nitrofurantoin,linezolid and chloramphenicol inhibiting 88%,86%,86%,81%and 81%of the MRS and 92.31%,94.88%,92.25%,89.09%and 86.56%VRS strains,respectively.Among herbal antimicrobials,the most effective herbal compound was carvacrol followed by thyme oil,cinnamledehyde and ajowan oil,inhibiting≥80%of the strains.VR was most common among S.xylosus,S.schleiferi,and S.delphini strains while S.caseolyticus strains had the least probability of having VR.Staphylococci from mastitis cases had the least probability of possessing VR wh

关 键 词：VRSA VRS MRSA MDR imipenem TIGECYCLINE NITROFURANTOIN CHLORAMPHENICOL LINEZOLID 

分 类 号：R97[医药卫生—药品]