BCL10基因多态性与急性胰腺炎的关联分析  

Correlation analysis of BCL10 gene polymorphism with acute pancreatitis

作　　者：严寒 徐萍[1] 王静[1] 娄晓丽[1] 李腾 YAN Han;XU Ping;WANG Jing;LOU Xiaoli;LI Teng(Department of Gastroenterology,the Central Hospital of Songjiang District,Shanghai 201600,China)

机构地区：[1]上海市松江区中心医院消化内科,上海201600

出　　处：《上海医药》2024年第19期72-76,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：上海市自然科学基金项目(20ZR1450900)。

摘　　要：目的:探讨B细胞淋巴瘤因子10(BCL10)基因多态性与急性胰腺炎(AP)的相关性。方法:选取90例AP患者为AP组,另选取87名健康者为对照组。查阅NCBI数据库,筛选BCL10的10个常见单核苷酸多态性(SNPs)位点,采用SNapShot法微测序法检测BCL10的SNPs位点。关联分析BCL10 SNPs位点与AP严重程度、发病原因、临床检查指标的关系,探讨AP的独立危险因素。结果:AP组BCL10 rs4949928位点C等位基因频率及CC+CT基因型较对照组升高(P<0.05)。二元logistic回归分析显示糖尿病、饮酒史、BCL10 rs4949928位点C基因是AP的独立危险因素(P<0.05)。结论:BCL10基因多态性可能与AP发病相关,rs4949928位点C等位基因突变是相关原因。Objective:To explore the relations of B-cell lymphoma factor 10(BCL10)gene polymorphism with acute pancreatitis.Methods:A total of 90 patients with AP were selected as an AP group and 87 healthy people as a control group.The nucleotide database of National Center for Biotechnology Information was searched to screen 10 single nucleotide polymorphisms(SNPs)of BCL10,and the SNPs of BCL10 was detected by SNapShot micro sequencing.The relationship between BCL10 SNPs loci and the severity,pathogenesis and clinical examination indexes of AP were analyzed by correlation analysis,and the independent risk factors of AP were discussed.Results:The frequencies of CC+CT genotype and C allelic gene of BCL10 rs4949928 in the AP group were significantly higher than those in the control group(P<0.05).The analysis of binary logistic regression model showed that history of diabetes,alcohol drinking and the C allelic gene of BCL10 were independent risk factors for AP(P<0.05).Conclusion:BCL10 gene polymorphism is associated with AP and C allelic gene of BCL10 rs4949928 is the associated cause.

关 键 词：BCL10 单核苷酸多态性 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统] R363.14[医药卫生—内科学]