supported by the National Natural Science Foundation of China(81570211,31670904);the Tsinghua-Peking Center for Life Sciences。
B-cell lymphoma 10(Bcl10) is a scaffolding protein that functions as an upstream regulator of NF-κB signaling by forming a complex with Mucosa-associated lymphoid tissue lymphoma translocation protein 1(Malt1) and CA...
supported by grants from the National Natural Science Foundation of China(31770937,31970848,82001677,31970892,81788101,31570914,and 81222039);National Key R&D Program of China(2018YFA0507401);the"Shuguang Program"of the Shanghai Education Development Foundation and the Shanghai Municipal Education Commission(15SG32);the Program of Shanghai Subject Chief Scientist(18XD1405200).
Sensing of pathogenic nucleic acids by pattern recognition receptors(PRR)not only initiates anti-microbe defense but causes inflammatory and autoimmune diseases.E3 ubiquitin ligase(s)critical in innate response need t...
Human BCL10 (hBCL10) protein is a signal transduction molecule originally identified because of its direct involvement in a subset of mucosa-associated lymphoid tissue (MALT) lymphomas, and later recognized as a cruci...