Calotropis procera:a review of molecular mechanisms,bioavailability,and potential anticancer property  

作　　者：Saqib Nawaz Abdul Wajid Asif Nawaz Hanif Ullah Safia Arbab Sawar Khan Aamir Khan Muhammad Sohail Abdul Qadeer 

机构地区：[1]Shanghai Veterinary Research Institute,The Chinese Academy of Agricultural Sciences(CAAS),Shanghai 200241,China [2]Faculty of Pharmacy,Gomal University Dera Ismail Khan,Dera Ismail Khan 29111,Pakistan [3]Faculty of Agriculture,The University of Agriculture,Dera Ismail Khan,Dera Ismail Khan 29111,Pakistan [4]School of Nursing,West China Hospital,Sichuan University,Chengdu 610041,China [5]Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China [6]Department of Cell Biology,School of Life Sciences,Central South University,Changsha 410013,China [7]Livestock and Dairy Development(Extension),Peshawar 25000,Pakistan [8]School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation,Yantai University,Yantai 264005,China.

出　　处：《Biomedical Engineering Communications》2024年第4期39-49,共11页生物医学工程通讯

基　　金：this manuscript sincerely acknowledge Central South University for their support through the postdoctoral research initiation grant(164990011).

摘　　要：Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in Cp,including cardenolides,flavonoids,and terpenoids,which exhibit cytotoxic effects against various cancer cells.These compounds function through multiple mechanisms,such as inducing apoptosis,inhibiting cell proliferation,suppressing angiogenesis,and modulating oxidative stress.Preclinical studies demonstrate that Cp extracts effectively reduce tumor size and improve survival rates in animal models.Furthermore,Cp influences key signaling pathways like PI3K/Akt and NF-κB,which contribute to its anticancer potential.Its therapeutic effects extend beyond oncology,encompassing,antinociceptive,anticonvulsant,antimalarial,anthelmintic,antioxidant,antidiabetic,myocardial infarction prevention,schizontocidal,antimicrobial,anti-inflammatory,larvicidal,immunomodulatory,antiulcer,Antifertility,antidiarrheal,estrogenic,and Dermatophytic properties.Despite the promising preclinical data,further investigation is necessary to address challenges such as bioavailability,toxicity,and the standardization of Cp-based treatments.This review highlights the therapeutic promise of Cp as a complementary anticancer agent while emphasizing the need for rigorous clinical trials to confirm its safety and efficacy.

关 键 词：Calotropisprocera ANTICANCER PI3K/AKT NF-ΚB 

分 类 号：R73[医药卫生—肿瘤]