侵袭性纤维瘤病的^(18)F-FDG PET/CT显像特征  

Characteristics of aggressive fibromatosis in ^(18)F-FDG PET/CT imaging

作　　者：李超伟 房娜[1] 靳飞 姜雯雯 曾磊[1] 刘翠玉[1] 隋玉栋 王艳丽[1] Li Chaowei;Fang Na;Jin Fei;Jiang Wenwen;Zeng Lei;Liu Cuiyu;Sui Yudong;Wang Yanli(Department of Molecular Imaging,the Affiliated Qingdao Central Hospital of Qingdao University,the Second Affiliated Hospital of Medical College of Qingdao University,Qingdao 266042,China)

机构地区：[1]青岛大学附属青岛市中心医院,青岛大学第二临床医学院分子影像科,青岛266042

出　　处：《国际放射医学核医学杂志》2024年第9期545-549,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：青岛市医疗卫生重点学科建设项目(青卫政字[2022]6号);青岛市医药卫生科研计划(2021-WJZD067)。

摘　　要：目的探讨侵袭性纤维瘤病(AF)的^(18)F-氟脱氧葡萄糖(FDG)PET/CT显像特征.方法回顾性分析2010年10月至2021年12月在青岛大学附属青岛市中心医院经组织病理学检查结果证实为AF的14例患者[男性5例、女性9例,年龄(45.0±14.8)岁]的临床及^(18)F-FDG PET/CT显像资料,记录病灶的位置、大小、形态、密度、边界和周围侵犯情况、远处转移情况、最大标准化摄取值(SUV_(max))、肿瘤代谢体积(MTV)、病灶糖酵解总量(TLG).采用Spearman相关分析评价病灶SUV_(max)、MTV、TLG与最大径的相关性.结果病灶位置:5例位于右下腹壁、9例位于腹壁外(肩背部4例、右侧胸壁3例、右侧大腿1例、右侧腋窝皮下1例).病灶最大径:(3.5±2.7)cm,范围1.0~8.2 cm.病灶形态:类圆形3例、梭形9例、不规则浸润状2例.病灶密度:12例密度较均匀、2例密度不均匀伴囊变.病灶边界和周围侵犯情况:12例病灶与邻近组织分界清楚、1例与同侧竖脊肌分界不清并累及对侧竖脊肌、1例侵犯局部肩胛骨致相应骨皮质增厚.所有患者均无远处转移.14例病灶的SUV_(max)、MTV、TLG分别为3.96(2.91,12.82)、2.10(1.46,29.55)cm^(3)、19.10(2.91,79.04)g.Spearman相关分析结果显示,病灶SUV_(max)与最大径无相关性(r=-0.018,P>0.05);MTV、TLG均与最大径呈正相关(r=0.901、0.847,均P<0.01).14例患者PET/CT显像中,11例为浅部病灶(紧邻皮下脂肪层的肌肉、筋膜或腱膜区的病灶),^(18)F-FDG代谢轻度增高,SUV_(max)为3.40(2.90,4.20);3例为深部病灶(非紧邻皮下脂肪层的肌肉、筋膜或腱膜区的病灶),^(18)F-FDG代谢明显增高,SUV_(max)分别为12.82、13.50、11.50.结论AF在^(18)F-FDG PET/CT显像上具有一定的特征;当病灶位于浅部时密度较低且^(18)F-FDG代谢轻度增高,当病灶位于深部时^(18)F-FDG代谢明显增高;^(18)F-FDG PET/CT显像对AF的诊断、与邻近结构关系及分期的判断有重要价值.Objective To investigate the ^(18)F-fluorodexyglucose(FDG)PET/CT imaging characteristics of aggressive fibromatosis(AF).Methods A retrospective analysis was conducted on the clinical data and ^(18)F-FDG PET/CT images of 14 patients(5 males,9 females;aged(45.0±14.8)years)with histopathologically confirmed AF admitted to the Affiliated Qingdao Central Hospital of Qingdao University from October 2010 to December 2021.The location,size,shape,density,boundary and surrounding invasion,distant metastasis,maximum standardized uptake value(SUV_(max)),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)of the lesions were measured and recorded.Spearman correlation analysis was used to evaluate the correlation of SUV_(max),MTV,and TLG with the maximum diameter.Results The location of all the lesions could be divided into right lower abdominal wall(five cases)and extra-abdominal wall(nine cases),including four cases in the dorsal shoulder,three cases in the right chest wall,one case in the right thigh,and one case in the right subcutaneous axilla.The maximum diameter of the lesions was(3.5±2.7)cm with a range of 1.0–8.2 cm.The morphology of all the lesions could be classified as round-like(three cases),pyknotic(nine cases),and irregularly infiltrated(two cases).The density of all the lesions was divided into homogeneous(12 cases)and inhomogeneous with cysts(two cases).The boundaries of all the lesions were divided into clearly delineated(12 cases)and indistinctly delineated(two cases).For the two cases with indistinct boundaries,one had indistinct delineation of the ipsilateral erector spinae muscle and involvement of the contralateral erector spinae muscle.The other exhibited invasion of the local scapula,causing the thickening of the corresponding bone cortex.All the patients had no distant metastasis.The SUV_(max),MTV,and TLG of all the lesions were 3.96(2.91,12.82),2.10(1.46,29.55)cm^(3),and 19.10(2.91,79.04)g,respectively.No correlation was found between SUV_(max) and the maximum diameter(r=−0.018,P>0.05).

关 键 词：纤维瘤病 侵袭型 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 

分 类 号：R730.44[医药卫生—肿瘤] R738.6[医药卫生—临床医学]