A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy  

作　　者：Yu-jie Liu Su-he Dong Wen-hao Hu Qiao-ling Chen Shao-fu Zhang Kai Song Zhen-chuan Han Meng-meng Li Zhi-tao Han Wei-bo Liu Xue-song Zhang 

机构地区：[1]Department of Orthopaedics,The Fourth Medical Centre,Chinese PLA General Hospital,51 Fucheng Road,Haidian District,Beijing,100048,China [2]Department of Orthopedic Oncology and Spine Tumor Center,Changzheng Hospital,Second Military Medical University,Shanghai,200001,China [3]PLA Rocket Force Characteristic Medical Center,Beijing,100088,China [4]Department of Anesthesiology,The Fourth Medical Centre,Chinese PLA General Hospital,51 Fucheng Road,Haidian District,Beijing,100048,China [5]School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,210023,Jiangsu,China

出　　处：《Bioactive Materials》2024年第6期157-167,共11页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.82373297).

摘　　要：Much effort has been devoted to improving treatment efficiency for osteosarcoma(OS).However,most current approaches result in poor therapeutic responses,thus indicating the need for the development of other therapeutic options.This study developed a multifunctional nanoparticle,PDA-MOF-E-M,an aggregation of OS targeting,programmed death targeting,and near-infrared(NIR)-aided targeting.At the same time,a multifunctional nanoparticle that utilises Fe-MOFs to create a cellular iron-rich environment and erastin as a ferroptosis inducer while ensuring targeted delivery to OS cells through cell membrane encapsulation is presented.The combination of PDA-MOF-E-M and PTT increased intracellular ROS and LPO levels and induced ferroptosis-related protein expression.A PDA-based PTT combined with erastin showed significant synergistic therapeutic improvement in the anti-tumour efficiency of the nanoparticle in vitro and vivo.The multifunctional nanoparticle efficiently prevents the osteoclasia progression of OS xenograft bone tumors in vivo.Finally,this study provides guidance and a point of reference for clinical approaches to treating OS.

关 键 词：OSTEOSARCOMA image SYNERGISTIC 

分 类 号：R73[医药卫生—肿瘤] R318[医药卫生—临床医学]