Niobium carbide MXenzyme-Driven comprehensive cholesterol regulation for photoacoustic image-guided and anti-inflammatory photothermal ablation in atherosclerosis  

作　　者：Wenqi Pan Jingyun Cheng Xinyue Cao Yi Zheng Zhenyu Yang Wei Feng Yu Chen Rong Wu 

机构地区：[1]Department of Ultrasound,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200080,PR China [2]Materdicine Lab,School of Life Sciences,Shanghai University,Shanghai,200444,PR China [3]Shanghai Institute of Materdicine,Shanghai,200051,PR China

出　　处：《Bioactive Materials》2024年第6期565-579,共15页生物活性材料（英文）

基　　金：the Shanghai General Hospital Clinical Center Laboratory Animal Welfare&Ethics Committee(License number:2023AW017).

摘　　要：Foam cells play a pivotal role in the progression of atherosclerosis progression by triggering inflammation within arterial walls.They release inflammatory molecules that attract additional immune cells,leading to further macrophage recruitment and plaque development.In this study,we develop an osteopontin(OPN)antibody-conjugated niobium carbide(Nb_(2)C-aOPN)MXenzyme designed to selectively target and mildly ablate foam cells while reducing inflammation in the plaque microenvironment.This approach utilizes photonic hyperthermia to decrease plaque size by enhancing cholesterol regulation through both passive cholesterol outflow and positive cholesterol efflux.Nb_(2)C-aOPN MXenzyme exhibits multiple enzyme-mimicking properties,including catalase,superoxide dismutase,peroxidase and glutathione peroxidase,and acts as a scavenger for reactive oxygen and nitrogen species.The inhibition of reactive oxygen and nitrogen species synergizes with photothermal ablation to promote positive cholesterol efflux,leading to reduced macrophage recruitment and a shift in macrophage phenotype from M1 to M2.This integrative strategy on cholesterol regulation and anti-inflammation highlights the potential of multifunctional 2D MXenzyme-based nanomedicine in advancing atherosclerotic regression.

关 键 词：ATHEROSCLEROSIS MXenzyme Lipid regulation ANTI-INFLAMMATION THERANOSTICS 

分 类 号：R318[医药卫生—生物医学工程]