Carbon nanotubes targeted to the tumor microenvironment inhibit metastasis in a preclinical model of melanoma  

作　　者：Lorena García-Hevia Rym Soltani Jesús González Olivier Chaloin Cécilia Ménard-Moyon Alberto Bianco Mónica L.Fanarraga 

机构地区：[1]The Nanomedicine Group,Universidad de Cantabria-IDIVAL,Avda Herrera Oria s/n,39011,Santander,Spain [2]CNRS,Immunology,Immunopathology and Therapeutic Chemistry,UPR 3572,University of Strasbourg,ISIS,67000,Strasbourg,France

出　　处：《Bioactive Materials》2024年第4期237-247,共11页生物活性材料（英文）

基　　金：funded by ISCIII Projects ref.PI19/00349,PI22/00030,PI23/00261 co-funded by ERDF/ESF,“Investing in your future”,Ministerio de Ciencia e Innovación ref.TED2021-129248B-100;the Agence Nationale de la Recherche(ANR)through the LabEx project Chemistry of Complex Systems(ANR-10-LABX-0026_CSC);funding from the European Union’s Horizon Europe Research and Innovation Program(Marie Skłodowska-Curie Actions-Doctoral Networks)under the grant agreement 101073025(Melomanes);LGH thanks the Ministry of Innovation and Science of Spain for her Juan de la Cierva Incorporación grant(IJC2020-043746-I).

摘　　要：Despite notable progress in cancer therapy,metastatic diseases continue to be the primary cause of cancer-related mortality.Multi-walled carbon nanotubes(MWCNTs)can enter tissues and cells and interfere with the dynamics of the cytoskeletal nanofilaments biomimetically.This endows them with intrinsic anti-tumoral effects comparable to those of microtubule-binding chemotherapies such as Taxol®.In this study,our focus was on exploring the potential of oxidized MWCNTs in selectively targeting the vascular endothelial growth factor receptor(VEGFR).Our objective was to evaluate their effectiveness in inhibiting metastatic growth by inducing anti-proliferative,anti-migratory,and cytotoxic effects on both cancer and tumor microenvironment cells.Our findings demonstrated a significant reduction of over 80%in malignant melanoma lung metastases and a substantial enhancement in overall animal welfare following intravenous administration of the targeted biodegradable MWCNTs.Furthermore,the combination of these nanomaterials with the conventional chemotherapy agent Taxol®yielded a remarkable 90%increase in the antimetastatic effect.These results highlight the promising potential of this combined therapeutic approach against metastatic disease and are of paramount importance as metastasis is responsible for nearly 60,000 deaths each year.

关 键 词：Carbon nanomaterials Nanofilaments VASCULARIZATION Peptide conjugates ANGIOGENESIS 

分 类 号：R73[医药卫生—肿瘤] TB383[医药卫生—临床医学]