动态反应酸碱理论的发展及其在药物合成中的应用  

The Development of Dynamic Reaction Acid-Base Theory and Its Application in Drug Synthesis

作　　者：虞心红[1] 赵琳 李喆垚 林忠仁 Yu Xinhong;Zhao Lin;Li Zheyao;Lin Zhongren(Engineering Research Centre of Pharmaceutical Process Chemistry,Ministry of Education,Shanghai Key Laboratory of New Drug Design,School of Pharmacy and State Key Laboratory of Bioengineering Reactors.East China University of Science and Technology,Shanghai,200237)

机构地区：[1]华东理工大学药学院、制药过程化学教育部工程中心、上海市新药设计重点实验室生物反应器国家重点实验室,上海200237

出　　处：《化学通报》2024年第11期1338-1342,共5页Chemistry

摘　　要：酸碱理论的发展经历了漫长的时间,从简单的酸具有酸味、碱具有涩味到现在将酸碱理论应用到化合物合成和药物研发中,人们对酸碱的认识也越来越全面。本文介绍了从阿伦尼乌斯电离理论、布朗斯特质子理论、路易斯电子理论、溶剂体系酸碱理论、酸碱正负离子理论、勒克斯-弗勒德氧离子理论到软硬酸碱理论等酸碱理论,并在此基础上提出了动态反应酸碱理论。本文还列举了酸碱理论在有机合成和药物合成中的应用实例。Throughout the history of acid-base theory,its development has gone through various stages.Initially,it was limited to simple acids with sour taste and bases with astringency.Over time,people developed a more comprehensive understanding of acid-base theory and its applications.This led to using acid-base theory in compound synthesis and drug development.Today,our understanding of acid-base theory is more advanced and sophisticated.In this paper,we have conducted a review of several acid-base theories.Furthermore,we have presented the dynamic reaction acid-base theory and highlighted its various applications in organic and drug synthesis.

关 键 词：酸碱理论 动态反应酸碱理论 理论发展 实际应用 

分 类 号：O621.3[理学—有机化学] TQ460.1[理学—化学]