Pyroptosis:Induction and inhibition strategies for immunotherapy of diseases  

作　　者：Junjun Wu Hong Wang Pu Gao Songying Ouyang 

机构地区：[1]Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University,the Key Laboratory of Innate Immune Biology of Fujian Province,Biomedical Research Center of South China,Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education,College of Life Sciences,Fujian Normal University,Fuzhou 350117,China [2]CAS Key Laboratory of Infection and Immunity,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第10期4195-4227,共33页药学学报（英文版）

基　　金：supported by National Key R&D Program of China(2021YFC2301403);National Natural Science Foundation of China(22237003,82225028,82172287 and 22307019);Fujian Provincial Natural Science Foundation(2023J01506,China);Fujian Provincial Foundation for Education and Scientific Research Projects of Young and Middle-aged Teachers(JAT220044,China);Xiang An Biomedicine Laboratory(2023XAKJ0101011,China);Scientific Research Start-up Fund for High-Level Talents in Fujian Normal University(China);the Cultivation Plan for Science and Technology Innovation Team from the College of Life Sciences,Fujian Normal University(China).

摘　　要：Cell death is a central process for organismal health.Pyroptosis,namely pyroptotic cell death,is recognized as a critical type that disrupts membrane and triggers pro-inflammatory cytokine secretion via gasdermins,providing a robust form of cytolysis.Meanwhile,along with the thorough research,a great deal of evidence has demonstrated the dual effects of pyroptosis in host defense and inflammatory diseases.More importantly,the recent identification of abundant gasdermin-like proteins in bacteria and fungi suggests an ancient origin of pyroptosis-based regulated cell death in the life evolution.In this review,we bring a general overview of pyroptosis pathways focusing on gasdermin structural biology,regulatory mechanisms,and recent progress in induction and inhibition strategies for disease treatment.We look forward to providing an insightful perspective for readers to comprehend the frame and challenges of the pyroptosis field,and to accelerating its clinical application.

关 键 词：PYROPTOSIS Gasdermin INDUCTION INHIBITION IMMUNOTHERAPY Cell death Reactive oxygen species(ROS) Regulatory mechanism Structural biology 

分 类 号：R135.2[医药卫生—劳动卫生]