Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response:A combination of effective photodynamic therapy,autophagy,ferroptosis,and antitumor immunity  

作　　者：Jingru Wang Man Liu Jingwen Wang Zhuoyue Li Zhenhan Feng Meiqi Xu Hui Wang Hui Li Zhantao Li Jianming Yu Junwei Liu Qingchao Wei Shuang Zhang Xuan Zhang 

机构地区：[1]Department of Pharmaceutics,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China [2]Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences,Peking University,Beijing 100191,China [3]School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China [4]Ningbo Institute of Marine Medicine,Peking University,Ningbo 315832,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第10期4493-4508,共16页药学学报（英文版）

基　　金：support from the National Natural Science Foundation of China(No.81773646);the National Key Research and Development Program of China(2017YFA0205600);the Innovation Team of the Ministry of Education(No.BMU2017TD003,China).

摘　　要：We prepared biocompatible and environment-friendly zinc oxide nanoparticles(ZnO NPs)with upconversion properties and catalase-like nanozyme activity.Photodynamic therapy(PDT)application is severely limited by the poor penetration of UV-Visible light and a hypoxic tumor environment.Here,we used ZnO NPs as a carrier for the photosensitizer chlorin e6(Ce6)to construct zinc oxide-chlorin e6 nanoparticles(ZnO-Ce6 NPs),simultaneously addressing both problems.In terms of penetration,ZnO NPs convert 808 nm near-infrared light into 401 nm visible light to excite Ce6,achieving deep-penetrating photodynamic therapy under long-wavelength light.Interestingly,the ability to emit short-wavelength light under long-wavelength light is usually observed in upconversion nanoparticles.As nanozymes,ZnO NPs can catalyze the decomposition of hydrogen peroxide in tumors,providing oxygen for photodynamic action and relieving hypoxia.The enhanced photodynamic action produces a large amount of reactive oxygen species,which overactivate autophagy and trigger immunogenic cell death(ICD),leading to antitumor immunotherapy.In addition,even in the absence of light,ZnO and ZnO-Ce6 NPs can induce ferroptosis of tumor cells and exert antitumor effects.

关 键 词：Photodynamic therapy Near-infrared light Tissue penetration Catalase-like nanozyme Ferroptosis AUTOPHAGY IMMUNITY Zinc oxide nanoparticles 

分 类 号：R285[医药卫生—中药学]