Glycosylation:mechanisms,biological functions and clinical implications  

作　　者：Mengyuan He Xiangxiang Zhou Xin Wang 

机构地区：[1]Department of Hematology,Shandong Provincial Hospital,Shandong University,Jinan,Shandong 250021,China [2]Department of Hematology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250021,China [3]National Clinical Research Center for Hematologic Diseases,the First Affiliated Hospital of Soochow University,Suzhou 251006,China [4]Taishan Scholars Program of Shandong Province,Jinan,Shandong 250021,China [5]Branch of National Clinical Research Center for Hematologic Diseases,Jinan,Shandong 250021,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第9期3615-3647,共33页信号转导与靶向治疗（英文）

基　　金：supported by National Natural Science Foundation(No.82270200,No.82170189,No.82070203,No.81800194,No.81770210);Key Research and Development Program of Shandong Province(No.2018CXGC1213);Taishan Scholars Program of Shandong Province(No.tspd20230610);China Postdoctoral Science Foundation(No.2021T1404223);Translational Research Grant of NCRCH(No.2021WWB02,No.2020ZKMB01);Shandong Provincial Natural Science Foundation(ZR2021YQ51);Shandong Provincial Engineering Research Center of Lymphoma;Academic Promotion Program of Shandong First Medical University(No.2019QL018).

摘　　要：Protein post-translational modification(PTM)is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups,and has a profound effect on protein function.Glycosylation is one of the most common PTMs,in which polysaccharides are transferred to specific amino acid residues in proteins by glycosyltransferases.A growing body of evidence suggests that glycosylation is essential for the unfolding of various functional activities in organisms,such as playing a key role in the regulation of protein function,cell adhesion and immune escape.Aberrant glycosylation is also closely associated with the development of various diseases.Abnormal glycosylation patterns are closely linked to the emergence of various health conditions,including cancer,inflammation,autoimmune disorders,and several other diseases.However,the underlying composition and structure of the glycosylated residues have not been determined.It is imperative to fully understand the internal structure and differential expression of glycosylation,and to incorporate advanced detection technologies to keep the knowledge advancing.Investigations on the clinical applications of glycosylation focused on sensitive and promising biomarkers,development of more effective small molecule targeted drugs and emerging vaccines.These studies provide a new area for novel therapeutic strategies based on glycosylation.

关 键 词：CLINICAL DRUGS RESIDUES 

分 类 号：Q51[生物学—生物化学]