Drug tolerant persister cell plasticity in cancer:a revolutionary strategy for more effective anticancer therapies  

作　　者：Jun He Zejing Qiu Jingjing Fan Xiaohong Xie Qinsong Sheng Xinbing Sui 

机构地区：[1]Department of Medical Oncology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China [2]Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines of Zhejiang Province,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China [3]Department of Breast Surgery,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,Zhejiang,China [4]Department of Colorectal Surgery,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第9期3816-3839,共24页信号转导与靶向治疗（英文）

摘　　要：Non-genetic mechanisms have recently emerged as important drivers of anticancer drug resistance.Among these,the drug tolerant persister(DTP)cell phenotype is attracting more and more attention and giving a predominant non-genetic role in cancer therapy resistance.The DTP phenotype is characterized by a quiescent or slow-cell-cycle reversible state of the cancer cell subpopulation and inert specialization to stimuli,which tolerates anticancer drug exposure to some extent through the interaction of multiple underlying mechanisms and recovering growth and proliferation after drug withdrawal,ultimately leading to treatment resistance and cancer recurrence.Therefore,targeting DTP cells is anticipated to provide new treatment opportunities for cancer patients,although our current knowledge of these DTP cells in treatment resistance remains limited.In this review,we provide a comprehensive overview of the formation characteristics and underlying drug tolerant mechanisms of DTP cells,investigate the potential drugs for DTP(including preclinical drugs,novel use for old drugs,and natural products)based on different medicine models,and discuss the necessity and feasibility of anti-DTP therapy,related application forms,and future issues that will need to be addressed to advance this emerging field towards clinical applications.Nonetheless,understanding the novel functions of DTP cells may enable us to develop new more effective anticancer therapy and improve clinical outcomes for cancer patients.

关 键 词：DRUGS attracting TOLERANT 

分 类 号：R73[医药卫生—肿瘤]