Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death  

作　　者：Chintan Chhatbar Michael Schulz Roman Sankowski 

机构地区：[1]Institute of Neuropathology,Faculty of Medicine,University of Freiburg,Freiburg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第10期4175-4177,共3页信号转导与靶向治疗（英文）

基　　金：We acknowledge support by the Open Access Publication Fund of the University of Freiburg enabled and organized by Projekt DEAL;R.S.is supported by the IMMediate Advanced Clinician Scientist-Program,Department of Medicine II,Medical Center,University of Freiburg and Faculty of Medicine,University of Freiburg,funded by the Bundesministerium für Bildung und Forschung(Federal Ministry of Education and Research),01EO2103;Furthermore,R.S.is supported by the Fritz Thyssen Foundation.M.S.is supported by the German Research Foundation(DFG,SCHU3696/2-1).Open Access funding enabled and organized by Projekt DEAL.

摘　　要：In their recent publication in Cell,Sundaram,and colleagues identified a novel role for NOD-like receptor(NLR)family CARD domain containing 5(NLRC5)in heme-mediated cell death and inflammation.1 This process is initiated by Toll-like receptors 2 and 4 on the cell surface,which induces intracellular NAD+depletion and ROS production.

关 键 词：DEATH HEME NLR 

分 类 号：R730.3[医药卫生—肿瘤]