Imidazole functionalized photo-crosslinked aliphatic polycarbonate drug-eluting coatings on zinc alloys for osteogenesis,angiogenesis,and bacteriostasis in bone regeneration  

作　　者：Wei Zhang Miao Dai Ye Zhu Siyuan Li Ying Sun Xiaoya Liu Xiaojie Li 

机构地区：[1]Key laboratory of synthetic and biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Lihu Street 1800,Wuxi,214122,China

出　　处：《Bioactive Materials》2024年第7期549-562,共14页生物活性材料（英文）

基　　金：support for this work from the National Natural Science Foundation of China,China (52173127).

摘　　要：Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ions(Zn^(2+)),particularly in the early stage of implantation,and absence of bio-functions related to complex bone repair processes.Herein,a biodegradable aliphatic polycarbonate drug-eluting coating was fabricated on zinc-lithium(Zn-Li)alloys to inhibit Zn^(2+)release and enhance the osteogenesis,angiogenesis,and bacteriostasis of Zn alloys.Specifically,the photo-curable aliphatic polycarbonates were co-assembled with simvastatin and deposited onto Zn alloys to produce a drug-loaded coating,which was crosslinked by subsequent UV light irradiation.During the 60 days long-term immersion test,the coating showed distinguished stable drug release and Zn^(2+)release inhibition properties.Benefiting from the regulated release of Zn^(2+)and simvastatin,the coating facilitated the adhesion,proliferation,and differentiation of MC3T3-E1 cells,as well as the migration and tube formation of EA.hy926 cells.Astonishingly,the coating also showed remarkable antibacterial properties against both S.aureus and E.coli.The in vivo rabbit critical-size femur bone defects model demonstrated that the drug-eluting coating could efficiently promote new bone formation and the expression of platelet endothelial cell adhesion molecule-1(CD31)and osteocalcin(OCN).The enhancement of osteogenesis,angiogenesis,and bacteriostasis is achieved by precisely controlling of the released Zn^(2+)at an appropriate level,as well as the stable release profile of simvastatin.This tailored aliphatic polycarbonate drug-eluting coating provides significant potential for clinical applications of Zn alloys implants.

关 键 词：Zn alloy implant Aliphatic polycarbonate Drug-eluting coating OSTEOGENESIS ANGIOGENESIS 

分 类 号：TG146.13[一般工业技术—材料科学与工程] R318[金属学及工艺—金属材料]