Aldo-keto reductase 1B:Much learned,much more to do  

作　　者：Yaya Zhao Miaomiao Zhang Huaping Li Yiwen Yang Xiaofu Lu Junjing Yu Lei Pan 

机构地区：[1]The Center for Microbes,Development,and Health,Key Laboratory of Molecular Virology and Immunology,Shanghai Institute of Immunity and Infection,Chinese Academy of Sciences,Shanghai,China [2]CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing,China [3]CAS Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai,China [4]University of Chinese Academy of Sciences,Beijing,China

出　　处：《hLife》2024年第4期154-178,共25页健康科学（英文）

基　　金：supported by grants from the National Key Research and Development Program of China(2022YFC2303504);the National Natural Science Foundation of China(92157106,32270917,82003361);the Shanghai Municipal Sci-ence and Technology Major Project(2019SHZDZX02);the Shanghai Committee of Science and Technology,China(22ZR1469900);supported by Youth Innovation Promo-tion Association of CAS,China(YIPA2023291).

摘　　要：The aldo-keto reductase 1B(AKR1B)subfamily was initially known for its association with the pathogenesis of secondary diabetic complications such as retinopathy,neuropathy,nephropathy,and cataracts.Unfortunately,over the past few decades,all drug development efforts targeting this family have failed for one reason or another.Recently,a growing body of evidence showing the deep involvement of AKR1B in metabolic reprogramming and production of signaling metabolites has led to a re-evaluation of their role in the pathogenesis of several immunometabolism-related diseases,such as gastrointestinal diseases,psoriasis,congenital disorders of glycosylation,carcinogenesis,even progression,and acquired chemoresistance.Therefore,in this review,we will summarize the current knowledge of AKR1B,highlighting their potential function in regulating immune cell function and then inflammatory complications.We will also explore how discovering this new insight into this old enzyme is essential for envisioning potential therapeutic strategies to prevent or treat inflammatory diseases.

关 键 词：aldo-keto reductase 1B gastrointestinal diseases PSORIASIS congenital disorder of glycosylation CANCER aldo-keto reductase 1B inhibitor 

分 类 号：R318[医药卫生—生物医学工程]