Beyond low-density lipoprotein cholesterol levels:Impact of prior statin treatment on ischemic stroke outcomes  

作　　者：Zi-Mo Chen Jing-Lin Mo Kai-Xuan Yang Ying-Yu Jiang Chun-Juan Wang Xin Yang Yong Jiang Xia Meng Jie Xu Hao Li Li-Ping Liu Yi-Long Wang Xing-Quan Zhao Yong-Jun Wang Hong-Qiu Gu Zi-Xiao Li 

机构地区：[1]Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100071,China [2]China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing 100071,China [3]National Center for Healthcare Quality Management in Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing 100071,China [4]Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100071,China [5]Research Unit of Artificial Intelligence in Cerebrovascular Disease,Chinese Academy of Medical Sciences,Beijing 100071,China [6]Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《The Innovation》2024年第6期80-88,共9页创新（英文）

基　　金：supported by grants fromthe National Key R&D Programof China(grant numbers 2022YFC2504900 and 2022YFC2504902);Beijing Natural Science Foundation(grant number Z200016);the National Natural Science Foundation of China(grant numbers 82101360 and 82171270).

摘　　要：Although essential for cardiovascular therapy,the pleiotropic effects of statins on ischemic stroke lack clinical evidence.This study examined the effects of statins beyond low-density lipoprotein cholesterol(LDL-C)levels on mortality and stroke severity.A total of 825,874 patients with ischemic stroke were included in this study,of whom 125,650 statin users were 1:1 matched with non-users based on their LDL-C levels(±0.05 mmol/L),forming the LDL-C-matched cohort.Associations between preceding statin treatment,in-hospital mortality,and stroke severity(National Institutes of Health Stroke Scale scoreR16)were estimated by multivariate and conditional logistic regression models in overall cohort and LDL-C-matched cohort,respectively.

关 键 词：MORTALITY LIPOPROTEIN CHOLESTEROL 

分 类 号：R96[医药卫生—药理学]