Intelligent hydrogels for treating malignant melanoma  

作　　者：Guopu Chen Xiyu Wang Jiaye Li Ye Xu Yue Lin Fengyuan Wang 

机构地区：[1]Department of Burns and Plastic Surgery,Nanjing Drum Tower Hospital,School of Medicine,Southeast University,Nanjing 210009,China [2]Department of Dermatology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China

出　　处：《Engineered Regeneration》2024年第3期295-305,共11页再生工程（英文）

基　　金：supported by National Natural Science Foundation of China(82203961 and 82302816);Jiangsu science and technology project(BK20230145);Nanjing health science and technology development project(YKK23098).

摘　　要：Malignant melanoma(MM)is an extremely aggressive and fatal form of skin cancer that primarily affects the bottom layer of the epidermis and is associated with poor clinical outcomes.Early-stage MM is typically treated through surgical removal,while chemotherapy and radiotherapy are common conventional treatment options that come with harmful side effects.Emerging therapies such as immunotherapy,photodynamic therapy,biologic therapy,and photothermal therapy present hopeful options for treatment due to their effective and secure drug delivery methods.To address the limitations of current treatment options,advanced methods of drug delivery for subcutaneous MM are being developed,with hydrogels emerging as a promising alternative.To date,significant advancements have been made in the treatment of MM through the use of hydrogels-based drug delivery systems through focal plastering,injection,implantation,and microneedles.Recent research on hydrogel-based drug delivery systems that integrate multiple therapies for the treatment of subcutaneous MM is discussed in this review.

关 键 词：INTELLIGENT HYDROGEL MICRONEEDLE Drug delivery system Malignant melanoma 

分 类 号：R739.5[医药卫生—肿瘤]