Neuroprotection on ischemic brain injury by Mg^(2+)/H_(2) released from endovascular Mg implant  

作　　者：Yang Zhang Hongkang Zhang Miaowen Jiang Xiaofeng Cao Xiaoxiao Ge Baoying Song Jing Lan Wenhao Zhou Zhengfei Qi Xuenan Gu Juzhe Liu Yufeng Zheng Ming Li Xunming Ji 

机构地区：[1]Department of Neurology and Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,100053,China [2]China-America Institute of Neuroscience and Beijing Institute of Geriatrics,Xuanwu Hospital,Capital Medical University,Beijing,100053,China [3]School of Materials Science and Engineering,Peking University,Beijing,100871,China [4]Beijing Institute for Brain Disorders,Capital Medical University,Beijing,100069,China [5]Biomaterials Research Center,Northwest Institute for Non-ferrous Metal Research,Xi’an,710016,China [6]School of Bioengineering,Beihang University,Beijing,100191,China [7]The Key Laboratory of Resources and Environmental System Optimization,Ministry of Education,College of Environmental Science and Engineering,North China Electric Power University,Beijing,100096,China

出　　处：《Bioactive Materials》2024年第12期124-139,共16页生物活性材料（英文）

基　　金：funded by National Natural Science Foundation of China(82027802,82102220);Research Funding on Translational Medicine from Beijing Municipal Science and Technology Commission(Z221100007422023);Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(YGLX202325);Non-profit Central Research Institute Fund of Chinese Academy of Medical(2023-JKCS-09);Beijing Association for Science and Technology Youth Talent Support Program(BYESS2022081);Science and Technology Innovation Service Capacity Building Project of Beijing Municipal Education Commission(11000023T000002157177);Outstanding Young Talents Program of Capital Medical University(B2305),Beijing Municipal Natural Science Foundation(7244510),Beijing Nova Program(20230484286).

摘　　要：recanalization.Yet,due to ischemia-reperfusion injury,over half of these patients still experience poor prognoses.Thus,neuroprotective treatment is imperative to alleviate the ischemic brain injury,and a proof-of-concept study was conducted on“biodegradable neuroprotective stent”.This concept is premised on the hypothesis that locally released Mg^(2+)/H_(2) from Mg metal within the bloodstream could offer synergistic neuroprotection against reperfusion injury in distant cerebral ischemic tissues.Initially,the study evaluated pure Mg’s neuroactive potential using oxygen-glucose deprivation/reoxygenation(OGD/R)injured neuron cells.Subsequently,a pure Mg wire was implanted into the common carotid artery of the transient middle cerebral artery occlusion(MCAO)rat model to simulate human brain ischemia/reperfusion injury.In vitro analyses revealed that pure Mg extract aided mouse hippocampal neuronal cell(HT-22)in defending against OGD/R injury.Additionally,the protective effects of the Mg wire on behavioral abnormalities,neural injury,blood-brain barrier disruption,and cerebral blood flow reduction in MCAO rats were verified.Conclusively,Mg-based biodegradable neuroprotective implants could serve as an effective local Mg^(2+)/H_(2) delivery system for treating distant cerebral ischemic diseases.

关 键 词：MAGNESIUM Acute ischemic stroke NEUROPROTECTION Biodegradable implantation Hydrogen 

分 类 号：R741[医药卫生—神经病学与精神病学]