Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants  

作　　者：Siqi Jin Yameng Yu Ting Zhang Daping Xie Yufeng Zheng Chunming Wang Yunsong Liu Dandan Xia 

机构地区：[1]Department of Dental Materials,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&NHC Key Laboratory of Digital Stomatology&NMPA Key Laboratory for Dental Materials,Beijing,100081,China [2]School of Materials Science and Engineering,Peking University,Beijing,100871,China [3]State Key Laboratory in Quality Research of Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao SAR,999078,China [4]Department of Prosthodontics,Peking University School and Hospital of Stomatology,Beijing,100081,China [5]International Research Organization for Advanced Science and Technology(IROAST),Kumamoto University,2-39-2 Kumamoto,860-8555,Japan

出　　处：《Bioactive Materials》2024年第12期404-432,共29页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2023YFC2412600);the National Natural Science Foundation of China(52271243,52171233,82370924);the NSFC-RFBR Joint Research Scheme(82361138575);the Beijing Nova Program(20230484459);the Beijing Natural Science Foundation(7242173);the Clinical Medicine Plus X-Young Scholars Project of Peking University;the Fundamental Research Funds for the Central Universities(PKU2024LCXQ014).

摘　　要：Soft tissue seal around the transmucosal region of dental implants is crucial for shielding oral bacterial invasion and guaranteeing the long-term functioning of implants.Compared with the robust periodontal tissue barrier around a natural tooth,the peri-implant mucosa presents a lower bonding efficiency to the transmucosal region of dental implants,due to physiological structural differences.As such,the weaker soft tissue seal around the transmucosal region can be easily broken by oral pathogens,which may stimulate serious inflammatory responses and lead to the development of peri-implant mucositis.Without timely treatment,the curable peri-implant mucositis would evolve into irreversible peri-implantitis,finally causing the failure of implantation.Herein,this review has summarized current surface modification strategies for the transmucosal region of dental implants with improved soft tissue bonding capacities(e.g.,improving surface wettability,fabricating micro/nano topographies,altering the surface chemical composition and constructing bioactive coatings).Furthermore,the surfaces with advanced soft tissue bonding abilities can be incorporated with antibacterial properties to prevent infections,and/or with immunomodulatory designs to facilitate the establishment of soft tissue seal.Finally,we proposed future research orientations for developing multifunctional surfaces,thus establishing a firm soft tissue seal at the transmucosal region and achieving the long-term predictability of dental implants.

关 键 词：Surface modifications Dental implant transmucosal region Soft tissue seal ANTIBACTERIAL IMMUNOMODULATION 

分 类 号：R78[医药卫生—口腔医学]