Dental pulp regeneration strategies:A review of status quo and recent advances  

作　　者：Xin-Lu Li Wei Fan Bing Fan 

机构地区：[1]The State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,237 Luoyu Road,430079,Wuhan,China

出　　处：《Bioactive Materials》2024年第8期258-275,共18页生物活性材料（英文）

基　　金：funded by the National Natural Science Foundation of China(Grant No.82270968&82170943);the Top Youth Talent in Medicine Program of Hubei Province,China.

摘　　要：Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods for pulp diseases include the root canal therapy,vital pulp therapy and regenerative endodontic therapy.Regenerative endodontic therapy serves the purpose of inducing the regeneration of new functional pulp tissues through autologous revascularization or pulp tissue engineering.This article first discusses the current clinical methods and reviews strategies as well as the research outcomes regarding the pulp regeneration.Then the in vivo models,the prospects and challenges for regenerative endodontic therapy were further discussed.

关 键 词：Pulp regeneration REVASCULARIZATION SCAFFOLD Growth factor Cell-homing 

分 类 号：R78[医药卫生—口腔医学]