Injectable citrate-based polyurethane-urea as a tug-of-war-inspired bioactive self-expansive and planar-fixing screw augmented bone-tendon healing  

作　　者：Meihan Tao Zhou Fang Yuting Zhu Yan Ju Zhiguo Hou Meimei Fu Zhihui Lu Daozhang Cai Jian Yang Jinshan Guo 

机构地区：[1]Department of Orthopedic Surgery,Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases,The Third Affiliated Hospital of Southern Medical University,Guangzhou,510630,PR China [2]Department of Histology and Embryology,NMPA Key Laboratory for Safety Evaluation of Cosmetics,School of Basic Medical Sciences,Southern Medical University,Guangzhou,510515,PR China [3]Regenerative Medicine and Tissue Repair Material Research Center,Huangpu Institute of Materials,Guangzhou New Materials Science Center,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,88 Yonglong Avenue of Xinlong Town,Guangzhou,511363,PR China [4]Research Center for Industries of the Future,Biomedical Engineering Program,School of Engineering,Westlake University,Hangzhou,Zhejiang,310030,PR China [5]CAS Key Laboratory of High-Performance Synthetic Rubber and its Composite Materials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,5625 Renmin Street,Changchun,130022,PR China

出　　处：《Bioactive Materials》2024年第11期108-126,共19页生物活性材料（英文）

基　　金：Youth Talent of Guangdong Special Support Program(0620220207);Natural Science Foundation of China(Grant Nos.U21A2099,82272453,and 82102545);China Postdoctoral Science Foundation(Grant No.2022M721515);Basic and Applied Basic Research Project of Guangzhou City(202201011774);Open Program from Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Disease.

摘　　要：Inspired by tug-of-war,a game-changing bone-tendon fixation paradigm was developed.Specifically,injectable citrate-based bioactive self-expansive and planar-fixing screw(iCSP-Scr)consisting of reactive isocyanate(NCO)terminalized citrate-based polyurethane,proanthocyanidin modified hydroxyapatite(HAp)and water(with/without porogen)was developed and administrated in the bone-tendon gap.Instead of the“point to point”tendon fixation by traditional interface screws,along with the moisture-induced crosslinking and expansion of iCSP-Scr within the confined space of the irregularly shaped bone-tendon gap,the tendon graft was evenly squeezed into the bone tunnel in a“surface to surface”manner to realize strong and stable bone-tendon fixation via physical expansion,mechanical interlocking and chemical bonding(between–NCO and the–NH2,–SH groups on bone matrix).The optimized iCSP-Scr exhibited rapid crosslinking,moderate expansion rate,high porosity after crosslinking,as well as tunable elasticity and toughness.The iCSP-Scr possessed favorable biodegradability,biocompatibility,and osteoinductivity derived from citrate,PC and HAp,it was able to promote osteogenesis and new bone growth inward of bone tunnel thus further enhanced the bone/iCSP-Scr mechanical interlock,ultimately leading to stronger tendon fixation(pull-out force 106.15±23.15 N)comparing to titanium screws(93.76±17.89 N)after 14 weeks’ACL reconstruction in a rabbit model.The iCSP-Scr not only can be used as a self-expansive screw facilitating bone-tendon healing,but also can be expanded into other osteogenic application scenarios.

关 键 词：Polyurethane INJECTABLE Self-expansive Planar-fixing CITRATE 

分 类 号：R318[医药卫生—生物医学工程]