A functional analysis of a resorbable citrate-based composite tendon anchor  

作　　者：Arun Thirumaran Meletios-Nikolaos Doulgkeroglou Magesh Sankar Jeremiah T.Easley Ben Gadomski Anup Poudel Manus Biggs 

机构地区：[1]Centre for Research in Medical Devices(CÚRAM),University of Galway,Ireland [2]Department of Mechanical Engineering,Colorado State University,USA

出　　处：《Bioactive Materials》2024年第11期207-220,共14页生物活性材料（英文）

基　　金：Foundation Ireland(SFI)and the European Regional Development Fund(Grant No.13/RC/2073).

摘　　要：Rapid and efficient tendon fixation to a bone following trauma or in response to degenerative processes can be facilitated using a tendon anchoring device.Osteomimetic biomaterials,and in particular,bio-resorbable polymer composites designed to match the mineral phase content of native bone,have been shown to exhibit osteoinductive and osteoconductive properties in vivo and have been used in bone fixation for the past 2 decades.In this study,a resorbable,bioactive,and mechanically robust citrate-based composite formulated from poly(octamethylene citrate)(POC)and hydroxyapatite(HA)(POC-HA)was investigated as a potential tendon-fixation biomaterial.In vitro analysis with human Mesenchymal Stem Cells(hMSCs)indicated that POC-HA composite materials supported cell adhesion,growth,and proliferation and increased calcium deposition,alkaline phosphatase production,the expression of osteogenic specific genes,and activation of canonical pathways leading to osteoinduction and osteoconduction.Further,in vivo evaluation of a POC-HA tendon fixation device in a sheep metaphyseal model indicates the regenerative and remodeling potential of this citrate-based composite material.Together,this study presents a comprehensive in vitro and in vivo analysis of the functional response to a citrate-derived composite tendon anchor and indicates that citrate-based HA composites offer improved mechanical and osteogenic properties relative to commonly used resorbable tendon anchor devices formulated from poly(L-co-D,l-lactic acid)and tricalcium phosphate PLDLA-TCP.

关 键 词：CITRATE OSTEOINDUCTIVE Tendon anchor COMPOSITE 

分 类 号：TB33[一般工业技术—材料科学与工程]