The impact of the novel starch-lipid complexes on the glucolipids metabolism, inflammation, and gut dysbiosis of type 2 diabetes mellitus rats  

作　　者：Yingshuang Lu Renbing Qin Jin Wang Fengjuan Xiang Yan Zhang Bowei Zhang Dancai Fan Huan Lü Xuemeng Ji Shujun Wang Shuo Wang 

机构地区：[1]Tianjin Key Laboratory of Food Science and Health,School of Medicine,Nankai University,Tianjin 300071,China [2]School of Food Science,Henan Institute of Science and Technology,Xinxiang 453600,China [3]State Key Laboratory of Food Nutrition and Safety,Tianjin University of Science&Technology,Tianjin 300457,China

出　　处：《Food Science and Human Wellness》2024年第6期3210-3223,共14页食品科学与人类健康（英文）

基　　金：the National Natural Science Foundation of China(3203000230);the Fundamental Research Funds for the Central Universities,Nankai University(63231172);the Natural Science Foundation of Henan(222300420158),for supporting this research.

摘　　要：It has been widely accepted that resistant starch(RS)provides numerous health benefits for human.In this research,we aimed at evaluating the performance of novel starch-lipid complexes,RS5,in comparison with RS2 on physical features,glucolipids metabolism,inflammation,and gut microbiota profiles of type 2 diabetes mellitus(T2DM)rats.The T2DM model was established by streptozotocin injection to the high-fat-sugar fed rats.According to a serial of biochemical analyses,we found that RS5 diets were strongly correlated with enhanced homeostatic model assessment for insulin secretion(HOMA-IS),high-density lipoprotein cholesterol(HDL-C),adiponectin(ADP),insulin action index(IAI),glucagon-like peptide-1(GLP1),and short-chain fatty acids(SCFAs)in T2DM rats whilst negatively associated with the low-density lipoprotein(LDL-C)and inflammatory cytokines,showing the capabilities to ameliorate T2DM symptoms by regulation of glucolipid metabolism,gut metabolites,and inflammation.On the other hand,RS2-enriched supplementations were influential in the mediation of insulin secretion to improve glucose metabolism.The increasing evidence collected herein suggested that intestinal microbiota could mediate glucolipids metabolism and alleviate inflammation after certain microflora nourished by RS.In addition,RS intake made an impact on phosphoinositide 3-kinase/protein kinase B signaling pathway that might contribute to the improvement of glucose metabolism,insulin resistance,and inflammatory responses.

关 键 词：Resistant starch Type 2 diabetes Glucolipid metabolism Gut microbiota INFLAMMATION 

分 类 号：TS201.4[轻工技术与工程—食品科学] R587.1[轻工技术与工程—食品科学与工程]