Microbial phenolic metabolites are associated with better frontal lobe cognition  

作　　者：Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Castañer Ramon Estruch Emili Ros Rosa M.Lamuela-Raventós 

机构地区：[1]Departament de Nutrició,Ciències de l’Alimentaciói Gastronomía,Facultat de Farmacia,Universitat de Barcelon(UB),Barcelona 08028,Spain [2]Institut de Nutriciói Seguretat Alimentària(INSA),Universitat de Barcelona(UB),Santa Coloma de Gramanet 08034,Spain [3]CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN),Instituto de Salud Carlos Ⅲ,Madrid 28029,Spain [4]Lipid Clinic,Endocrinology and Nutrition Service,Institut d'Investigacions Biomèdiques August Pi i Sunyer,Hospital Clínic,Barcelona 08036,Spain [5]Department of Preventive Medicine and Public Health,University of Navarra,IdiSNA,Pamplona 31008,Spain [6]Unit of Cardiovascular Risk and Nutrition,Institut Hospital del Mar de Investigaciones Médicas(IMIM),Barcelona 08007,Spain [7]Department of Internal Medicine,Hospital Clinic,Institut d’InvestigacióBiomèdica August Pi i Sunyer(IDIBAPS),University of Barcelona,Barcelona 08007,Spain [8]Department of Endocrinology,Hospital Clinic,IDIBAPS,Barcelona 08007,Spain

出　　处：《Food Science and Human Wellness》2024年第6期3266-3272,共7页食品科学与人类健康（英文）

基　　金：supported by the CICYT(AGL2016-75329-R PID2020-114022RB-I00);CIBEROBN from the Instituto de Salud Carlos III,ISCIII from the Ministerio de Ciencia,Innovación y Universidades(AEI/FEDER,UE);Generalitat de Catalunya(GC)(2017SGR 196).

摘　　要：With increasing life expectancy,neurodegenerative diseases have become one of the leading causes of illhealth in the elderly.Preventive strategies include following healthy diets,such as the Mediterranean diet,which is particularly rich in polyphenols,bioactive compounds with neuroprotective properties.The aim of this study was to assess the association of microbial phenolic metabolites(MPM)with cognition.This cross-sectional analysis was performed with 200 participants of the PREDIMED trial(Barcelona-Clinic recruitment center).A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM(protocatechuic acid,enterodiol glucuronide,enterolactone glucuronide,urolithin B glucuronide,and vanillic acid glucuronide),and cognitive function was evaluated with neuropsychological tests.Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM,and a score was calculated as the weighted sum of MPM.A higher MPM score was associated with better frontal lobe function.Among individual metabolites,vanillic acid glucuronide was correlated with frontal cognitive performance.Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2.A higher score for urinary multiMPM was associated with better frontal cognitive performance in an older Mediterranean population.

关 键 词：POLYPHENOLS NEURODEGENERATION MICROBIOTA Gut-brain axis PREDIMED 

分 类 号：TS201.4[轻工技术与工程—食品科学]