Silver carp muscle hydrolysate ameliorated atherosclerosis and liver injury in apoE^(-/-) mice: the modulator effects on enterohepatic cholesterol metabolism  

作　　者：Kai Wang Zixin Fu Yuqing Tan Hui Hong Jianping Wu Yongkang Luo 

机构地区：[1]Beijing Laboratory for Food Quality and Safety,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China [2]College of Food Science and Engineering,Yangzhou University,Yangzhou 225127,China [3]Department of Agricultural,Food and Nutritional Science,University of Alberta,Edmonton T6G 2P5,Canada

出　　处：《Food Science and Human Wellness》2024年第6期3325-3338,共14页食品科学与人类健康（英文）

基　　金：supported by the China Agriculture Research System(CARS-45),Natural Science Foundation of Jiangsu Province(BK20240918);the“Green Yangzhou Golden Phoenix”funding of Yangzhou(137013478).

摘　　要：Atherosclerosis(AS)is a major cause of cardiovascular diseases(CVDs)and a strong link with hepatic steatosis.Silver carp muscle hydrolysate(SCH)possess various beneficial activities but its effect on AS and hepatic steatosis is yet unknown.This study aimed to investigate the effects of SCH on AS lesions and hepatic steatosis using apoE-/-mice.Results showed that SCH significantly reduced the vascular AS plaques and alleviated hepatic steatosis lesions in apoE-/-mice.Consistent with this,the lipid levels both in circulation and liver were lowered by SCH.The mechanism analysis showed SCH down-regulated the expression of genes involved in lipoproteins production while up-regulated the expression of genes related to reverse cholesterol transport(RCT)in liver.Meanwhile,SCH remarkably promoted transintestinal cholesterol excretion(TICE)process in intestine,partly contributing to the reduction of blood lipids.The peptide profile data indicated LYF,HWPW,FPK,and YPR are the main peptides in SCH that play a vital role in alleviating AS lesions and hepatic steatosis.Our findings provided new knowledge for the application of SCH in ameliorating CVDs and liver diseases.

关 键 词：ATHEROSCLEROSIS Hepatic steatosis TRANSCRIPTOME Reverse cholesterol transport Peptide profile 

分 类 号：TS254.1[轻工技术与工程—水产品加工及贮藏工程]