Dietary (poly)phenol intake is associated with cardiometabolic health parameters in adolescents  

作　　者：Emily P.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau 

机构地区：[1]Department de Nutrició,Ciències de l’AlimentacióI Gastronomia,XIA,Facultat de Farmàcia i Ciències de l’alimentació,Institut de Recerca en Nutriciói Seguretat Alimentària(INSA-UB),Universitat de Barcelona,Barcelona 08028,Spain [2]Consorcio CIBER,M.P.Fisiopatología de la Obesidad y Nutrición(CIBERObn),Instituto de Salud Carlos Ⅲ(ISCIII),Madrid 28029,Spain [3]Department of Internal Medicine,Hospital Clínic,Institutd’Investigacions Biomèdiques August Pi I Sunyer(IDIBAPS),University of Barcelona,Barcelona 08036,Spain [4]Mediterranean Diet Foundation,Barcelona 08021,Spain [5]Foundation for Science,Health and Education(SHE),Barcelona 08008,Spain [6]Centro Nacional de Investigaciones Cardiovasculares(CNIC),Madrid 28029,Spain [7]The Zena and Michael A.Wiener Cardiovascular Institute,Icahn School of Medicine at Mount Sinai,New York 10029,USA [8]CIBER de Enfermedades Cardiovasculares(CIBERCV),Madrid 28029,Spain [9]Hospital Universitario Clínico San Carlos,Madrid 28040,Spain

出　　处：《Food Science and Human Wellness》2024年第6期3381-3390,共10页食品科学与人类健康（英文）

基　　金：supported by the SHE Foundation,“la Caixa”Foundation(LCF/PR/CE16/10700001);the Fundacióla Maratóde TV3(grant number 369/C/2016)and by the funding from Idilia Foods(FBG 311240);Support was also provided by the Ministerio de Ciencia,Innovación y Universidades(PID2020-114022RB-I00);CIBEROBN from the Instituto de Salud Carlos III,ISCIII from the Ministerio de Ciencia,Innovación y Universidades,(AEI/FEDER,UE);Generalitat de Catalunya.J.Martínez-Gómez is a postgraduate fellow of the Ministerio de Ciencia e Innovación of Spain at the Residencia de Estudiantes(2020–ongoing);R.F-J is a recipient of grant PI19/01704 funded by the Fondo de Investigación Sanitaria-Instituto de Salud Carlos III(ISCIII);co-funded by the European Regional Development Fund/European Social Fund“A way to make Europe”/“Investing in your future”.The CNIC is supported by the ISCIII,the Ministerio de Ciencia e Innovación(MCIN)and the Pro CNIC Foundation,and is a Severo Ochoa Center of Excellence(CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033);G.Santos-Beneit is the recipient of grant LCF/PR/MS19/12220001 funded by“la Caixa”Foundation(ID 100010434);A.Tresserra-Rimbau is a Serra Húnter Fellow.E.P.Laveriano-Santos is a FI-SDUR(EMC/503/2021)fellow from the Generalitat de Catalunya.

摘　　要：The protective role of(poly)phenols against metabolic disorders has been extensively studied in adults but not in adolescents.To assess associations of dietary(poly)phenols and their subclasses with cardiometabolic health parameters in adolescents.A cross-sectional study was conducted in 944 individuals aged 11–14 years enrolled in the SI!Program for Secondary Schools trial(NCT03504059).(Poly)phenol intake was assessed using semiquantitative food frequency questionnaires and the Phenol-Explorer database.The measured cardiometabolic parameters were waist circumference(WC)age-sex Z-score,blood pressure(BP)age-sex Z-score,blood glucose(BG),triglycerides(TG),and high-density lipoprotein cholesterol(HDL-c).Multilevel mixedeffect linear regression models were applied to examine the association between(poly)phenol quintiles and cardiometabolic health parameters.Compared to the lowest quintile,adolescents in the highest quintile of total(poly)phenol intake had lower WC Z-scores,mean arterial pressure Z-scores,and HDL-c after multivariable adjustment.The WC Z-scores and HDL-c were lower in the highest quintile of flavonoid intake compared to the lowest quintile.The highest quintile of phenolic acid intake was associated with a lower WC Z-score and TG levels,and the highest quintile of stilbene intake with lower BG and TG,and with higher HDL-c compared to the lowest quintile.A higher intake of(poly)phenols,especially flavonoids,phenolic acids,and stilbenes,was associated with better cardiometabolic parameters in adolescents.

关 键 词：PHYTOCHEMICAL RESVERATROL Lignan Flavan-3-ols ANTHOCYANIN Cardiovascular health TEENAGERS 

分 类 号：TS201.4[轻工技术与工程—食品科学]