Protective effects of Bifi dobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway  

作　　者：Xinqi Chen Yang Chen Catherine Stanton RPaul Ross Jianxin Zhao Bo Yang Wei Chen 

机构地区：[1]State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]International Joint Research Center for Probiotics&Gut Health,Jiangnan University,Wuxi 214122,China [4]APC Microbiome Ireland,University College Cork,Cork T12 YT20,Ireland [5]Teagasc Food Research Centre,Cork T12 YT20,Ireland [6]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China

出　　处：《Food Science and Human Wellness》2024年第6期3447-3460,共14页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(32072227,32021005);111 Project(BP0719028);the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province.

摘　　要：This study aimed to evaluate the effects of Bifi dobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms.B.breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid(DCA)and lithocholic acid(LCA)in the colon compared with those of the imiquimod(IMQ)-treated mice.Meanwhile,B.breve CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae UCG001.Additionally,the farnesoid X receptor(FXR)in the skin was activated and the expression of the Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)pathway was inhibited,and the downstream interleukin(IL)-17 and tumor necrosis factor(TNF)-αwere downregulated whereas IL-10 was up-regulated.Moreover,the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved.In conclusion,CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota,promoting the DCA production,regulating the FXR-TLR4/NF-κB pathway,diminishing proinflammatory cytokines,and regulating keratinocytes and epidermal barrier.These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.

关 键 词：PSORIASIS Bifi dobacterium breve Gut microbiota Secondary bile acids FXR-TLR4/NF-κB pathway 

分 类 号：TS201[轻工技术与工程—食品科学] R758.63[轻工技术与工程—食品科学与工程]