Diet with high content of advanced glycation end products induces oxidative stress damage and systemic inflammation in experimental mice: protective effect of peanut skin procyanidins  

作　　者：Li Zhao Xingxing Zhang Langzhi He Yubing Li Yue Yu Qun Lu Rui Liu 

机构地区：[1]College of Food Science and Engineering,Shanxi Agricultural University,Taigu 030801,China [2]College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China [3]Wuhan Engineering Research Center of Bee Products on Quality and Safety Control,Wuhan 430070,China [4]Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University),Ministry of Education,Wuhan 430070,China [5]Laboratory of Urban Agriculture in Central China,Ministry of Agriculture and Rural Affairs,Wuhan 430070,China

出　　处：《Food Science and Human Wellness》2024年第6期3570-3581,共12页食品科学与人类健康（英文）

基　　金：supported by the Doctoral Science Foundation of Shanxi Agricultural University(2023BQ34);Shanxi Province Work Award Fund Research Project(SXBYKY2022116).

摘　　要：Non-enzymatic glycation reaction in food can produce diet-derived advanced glycation end products(dAGEs),which have potential health risks.Thus,it is of great significance to find efficient substances to improve the negative effects induced by dAGEs on human health.This study investigated the intervening effects of peanut skin procyanidins(PSP)on the dAGEs-induced oxidative stress and systemic inflammation in experimental mice model.Results showed that the accumulation of AGEs in serum,liver,and kidney was significantly increased after mice were fed dAGEs(P<0.05).The expression of advanced glycation product receptor(RAGE)was also significantly increased in liver and kidney(P<0.05).PSP could not only effectively reduce the accumulation of AGEs in serum,liver and kidney of mice,but also reduce the expression of RAGE in liver and kidney of mice.And the levels of pro-inflammatory cytokines interleukin-6(IL-6),tumor necrosis factor(TNF-α),and IL-1βin serum of mice were significantly decreased(P<0.05),while the levels of antiinflammatory factor IL-10 were increased,and the inflammatory injury in mice was improved.In addition,the levels of superoxide dismutase(SOD),glutathione(GSH),catalase(CAT)in liver and kidney of mice were increased(P<0.05),and the level of malondialdehyde(MDA)was decreased(P<0.05),which enhanced the antioxidant capacity of mice in vivo,and improved the oxidative damage of liver and kidney.Molecular docking technique was used to confirm that the parent compound of procyanidins and its main metabolites,such as 3-hydroxyphenylacetic acid,could interact with RAGE,which might inhibit the activation of nuclear transcription factor(NF-κB),and ultimately reduce oxidative stress and inflammation in mice.

关 键 词：Peanut skin procyanidins Diet-derived advanced glycation end products Oxidative stress INFLAMMATION Interaction 

分 类 号：TS201.4[轻工技术与工程—食品科学]