Research Advancements in the Interplay between T3 and Macrophages  

作　　者：Liu YANG Meng-fei FU Han-yu WANG Hui SUN 

机构地区：[1]Department of Endocrinology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders,Wuhan,430022,China

出　　处：《Current Medical Science》2024年第5期883-889,共7页当代医学科学（英文）

摘　　要：3,3′,5-Triiodo-L-thyronine(T3)is a key endocrine hormone in the human body that plays crucial roles in growth,development,metabolism,and immune function.Macrophages,the key regulatory cells within the immune system,exhibit marked“heterogeneity”and“plasticity”,with their phenotype and function subject to modulation by local environmental signals.The interplay between the endocrine and immune systems is well documented.Numerous studies have shown that T3 significantly target macrophages,highlighting them as key cellular components in this interaction.Through the regulation of macrophage function and phenotype,T3 influences immune function and tissue repair in the body.This review comprehensively summarizes the regulatory actions and mechanisms of T3 on macrophages,offering valuable insights into further research of the immunoregulatory effects of T3.

关 键 词：3 3′ 5-triiodo-L-thyronine MACROPHAGES inflammatory response IMMUNITY regulatory mechanism 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]