Modification of contact lenses via metal-organic frameworks for glaucoma treatment  

作　　者：Alexey V.Yaremenko Roman O.Melikov Nadezhda A.Pechnikova Iaroslav B.Belyaev Alina Ringaci Tamara V.Yaremenko Aziz B.Mirkasymov Alexandr A.Tamgin Vladislav I.Rodionov Sofya M.Dolotova Grigory A.Plisko Evgeny D.Semivelichenko Anna S.Rogova Albert R.Muslimov Arina S.Ivkina Dmitry Yu.Ivkin Valery P.Erichev Sergey M.Deyev Sergey E.Avetisov Yongjiang Li Hai-Jun Liu Ivan V.Zelepukin 

机构地区：[1]Center for Nanomedicine and Department of Anesthesiology,Brigham and Women’s Hospital,Harvard Medical School,Boston,Massachusetts,USA [2]Aristotle University of Thessaloniki,Thessaloniki,Greece [3]Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences,Moscow,Russia [4]Moscow Center for Advanced Studies,Moscow,Russia [5]Faculty of Biology,Saint Petersburg State University,Saint Petersburg,Russia [6]Saint Petersburg Pasteur Institute,Saint Petersburg,Russia [7]Department of Chemistry,Boston University,Boston,Massachusetts,USA [8]Sechenov University,Moscow,Russia [9]Saint Petersburg State Chemical and Pharmaceutical University,Saint Petersburg,Russia [10]Peter the Great St.Petersburg Polytechnic University,Saint Petersburg,Russia [11]Sirius University of Science and Technology,Sirius,Russia [12]RM Gorbacheva Research Institute,Pavlov University,Saint Petersburg,Russia [13]Research Institute of Eye Diseases,Moscow,Russia [14]Department of Medicinal Chemistry,Uppsala University,Uppsala,Sweden

出　　处：《Aggregate》2024年第5期358-370,共13页聚集体（英文）

基　　金：Ministry of Science and Higher Education of the Russian Federation,Grant/Award Number:075-15-2024-536。

摘　　要：The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure.Here,human contact lenses are modified with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma treatment.Various metal-organic frameworks were screened for their attachment to lenses,loading with brimonidine,and drug-release properties.Opti-mized therapeutic ocular lenses conjugated with MIL-101(Cr)frameworks maintain optical transparency and power.Coating of lenses with MIL-101(Cr)nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the cornea.The hybrid lenses provided a 4.5-fold better decrease in eye pressure,compared by area under the curve(AUC)value to a commercially available brimonidine tartrate solution.Therapeutic lenses did not induce any notable eye irritation or corneal damage in vivo.The newly devel-oped hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases.

关 键 词：BRIMONIDINE contact lenses drug delivery GLAUCOMA intraocular pressure metal-organic frameworks NANOPARTICLES 

分 类 号：O64[理学—物理化学]