Bioinspired menstrual blood-derived stem cells-conditioned medium/polymersome nanoparticles for the treatment of carbon tetrachloride-induced acute liver failure in mice  

作　　者：Zuhong Li Qian Li Xiaoxi Ouyang Shima Tang Qiuhong Liu Yaqi Zhang Yanhong Zhang Xiaopeng Yu Danhua Zhu Ying Mu Lanjuan Li 

机构地区：[1]State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Medical Center for Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [2]Research Centre for Analytical Instrumentation,College of Control Science and Engineering,State Key Laboratory of Industrial Control Technology,Zhejiang University,Hangzhou,China

出　　处：《Aggregate》2024年第4期376-385,共10页聚集体（英文）

基　　金：National Key Research and Development Program of China,Grant/Award Numbers:2019YFC0840600,2019YFC0840609;Fundamental Research Funds for the Central Universities,Grant/Award Number:2022ZFJH003;Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Disease。

摘　　要：Acute liver failure is a life-threatening syndrome,for which liver transplantation is presently the most effective treatment.Unfortunately,such treatment is extremely limited by a shortage of donor organs.Stem cell therapy offers a promising treatment strategy for acute liver failure.Yet,therapeutic efficacy and potential are hampered by administration route and safety concerns.In this work,we fabricated menstrual blood-derived stem cells-conditioned medium/polymersome hybrid nanoparticles that were self-assembled from amphiphilic block copolymers via the direct hydra-tion method and encapsulated therapeutic bioactive factors within the aqueous core of vesicles.The merit of vesicular architecture enabled the loading capacity of dis-tinct proteins and the maintenance of biological activity.These hybrid nanoparticles can be steadily taken up into cytoplasm and promote hepatocyte proliferation in vitro.Prolonged in vivo circulation time brought higher accumulation in livers.The therapeutic nanoparticles alleviated hepatic injury and promoted liver recovery in mice with carbon tetrachloride-induced liver failure.Considering the feasibility and benefit of the hybrid nanoparticle therapy,it provided a potential strategy to treat acute liver failure.

关 键 词：acute liver failure MenSCs-conditioned medium NANOPARTICLES POLYMERSOMES 

分 类 号：R575.3[医药卫生—消化系统]