Oral administration microrobots for drug delivery  

作　　者：An Ren Jiarui Hu Changwei Qin Neng Xia Mengfei Yu Xiaobin Xu Huayong Yang Min Han Li Zhang Liang Ma 

机构地区：[1]State Key Laboratory of Fluid Power and Mechatronic Systems,Zhejiang University,Hangzhou 310058,China [2]School of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China [3]Department of Mechanical and Automation Engineering,The Chinese University of Hong Kong,Shatin NT,Hong Kong SAR,China [4]The Affiliated Stomatologic Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China [5]Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education,Key Laboratory of D&A for Metal-Functional Materials,School of Materials Science&Engineering,Tongji University,Shanghai,201804 China [6]Institute of Pharmaceutics,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China

出　　处：《Bioactive Materials》2024年第9期163-190,共28页生物活性材料（英文）

基　　金：the funding from National Key Research and Development Program of China,China(No.2018YFA0703000);The National Natural Science Foundation of China No.52275294.

摘　　要：Oral administration is the most simple, noninvasive, convenient treatment. With the increasing demands on thetargeted drug delivery, the traditional oral treatment now is facing some challenges: 1) biologics how toimplement the oral treatment and ensure the bioavailability is not lower than the subcutaneous injections;2)How to achieve targeted therapy of some drugs in the gastrointestinal tract? Based on these two issues, drugdelivery microrobots have shown great application prospect in oral drug delivery due to their characteristics offlexible locomotion or driven ability. Therefore, this paper summarizes various drug delivery microrobotsdeveloped in recent years and divides them into four categories according to different driving modes: magneticcontrolleddrug delivery microrobots, anchored drug delivery microrobots, self-propelled drug delivery microrobotsand biohybrid drug delivery microrobots. As oral drug delivery microrobots involve disciplines such asmaterials science, mechanical engineering, medicine, and control systems, this paper begins by introducing thegastrointestinal barriers that oral drug delivery must overcome. Subsequently, it provides an overview of typicalmaterials involved in the design process of oral drug delivery microrobots. To enhance readers’ understanding ofthe working principles and design process of oral drug delivery microrobots, we present a guideline for designingsuch microrobots. Furthermore, the current development status of various types of oral drug delivery microrobotsis reviewed, summarizing their respective advantages and limitations. Finally, considering the significantconcerns regarding safety and clinical translation, we discuss the challenges and prospections of clinical translationfor various oral drug delivery microrobots presented in this paper, providing corresponding suggestions foraddressing some existing challenges.

关 键 词：MICROROBOTS Gastrointestinal tract Oral administration Drug delivery BIOLOGICS 

分 类 号：R943[医药卫生—药剂学]