微小残留病灶检测技术原理与肿瘤诊疗模式革新  

The Principle of Detecting Minor Residual Lesions and the Innovation of Tumor Diagnosis and Treatment Mode

作　　者：高燕 王琛 胡海洋 Gao Yan;Wang Chen;Hu Haiyang(School of Life Science and Technology,China Pharmaceutical University,Nanjing,Jiangsu 211198;Central Laboratory of Pulmonary Hospital Affiliated to Tongji University,Shanghai 200092)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211198 [2]同济大学附属肺科医院中心实验室,上海200092

出　　处：《科技与健康》2024年第20期1-4,共4页Technology and Health

摘　　要：微小残留病灶(minimal residual disease,MRD)是指肿瘤患者接受治疗后残留在体内的少量肿瘤细胞,有效识别MRD可以优化肿瘤患者的治疗效果,提高患者的生存质量。因此,MRD检测技术已逐渐成为肿瘤诊疗领域的前沿热点。MRD检测技术的出现为全新肿瘤复发模式的探索提供了科学依据,MRD检测技术的成功应用是肿瘤诊疗领域的重大革新。分析了MRD检测技术的概念与发展历程,阐述了MRD检测的技术原理,总结了基于下一代测序(next-generation sequencing,NGS)技术以及基于血液循环肿瘤DNA(ctDNA)等高灵敏度MRD检测技术路径。对MRD技术面临的挑战与未来发展前景进行了展望。MRD检测技术在实现精准医疗和提高癌症治愈率方面具有巨大潜力。Minor residual disease(MRD)refers to the small amount of tumor cells remaining in the body of cancer patients after treatment.Effective identification of MRD can optimize the treatment effect of cancer patients and improve their quality of life.Therefore,MRD detection technology has gradually become a cutting-edge hotspot in thefield of tumor diagnosis and treatment.The emergence of MRD detection technology provides scientific basis for exploring new tumor recurrence patterns,and the successful application of MRD detection technology is a major innovation in thefield of tumor diagnosis and treatment.Analyzed the concept and development history of MRD detection technology,elucidated the technical principles of MRD detection,and summarized the high-sensitivity MRD detection technology paths based on next-generation sequencing(NGS)technology and circulating tumor DNA(ctDNA).The challenges and future development prospects of MRD technology were discussed,highlighting the enormous potential of MRD detection technology in achieving precision medicine and improving cancer cure rates.

关 键 词：微小残留病灶 CTDNA 液体活检 下一代测序 

分 类 号：R733.3[医药卫生—肿瘤]